Inorganic arsenic-induced intramitochondrial granules in mouse urothelium

Toxicologic Pathology
Shugo SuzukiSamuel M Cohen

Abstract

Based on epidemiological data, chronic exposure to high levels of inorganic arsenic in the drinking water is carcinogenic to the urinary bladder of humans. Recently, models have been developed involving transplacental administration of inorganic arsenic and subsequent administration of another substance that produces a low incidence of urogenital neoplasms. Administration of arsenite or arsenate in the diet or drinking water to five-to eight-week-old mice or rats rapidly induces urothelial cytotoxicity and regenerative hyperplasia. In mice administered arsenite, we observed eosinophilic intracytoplasmic granules present in the urothelial cells. These granules were not present in urothelial cells of untreated mice or in treated or untreated rats. By transmission electron microscopy, the granules were located within the mitochondrial matrix, that is, mitochondrial inclusions. Arsenic, primarily as arsenite, was present in partially purified mitochondria containing these granules. Cells containing the granules were not usually associated with degenerative changes. Lack of these granules in rats suggests that they are not necessary for inorganic arsenic-induced urothelial cytotoxicity or hyperplasia. These granules have also been o...Continue Reading

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Citations

Mar 10, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Masanao YokohiraSamuel M Cohen
Jun 8, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Whitney R WedelSamuel M Cohen
Oct 8, 2013·Toxicological Sciences : an Official Journal of the Society of Toxicology·Puttappa R DodmaneSamuel M Cohen
May 28, 2013·Critical Reviews in Toxicology·Ernst M BomhardSamuel M Cohen
Sep 18, 2013·Critical Reviews in Toxicology·Samuel M CohenMichal Eldan
Feb 9, 2017·Microscopy Research and Technique·Rui YangShaohui Wang
May 22, 2013·Toxicologic Pathology·Lora L ArnoldSamuel M Cohen
Jun 1, 2012·Toxicologic Pathology·Kendall S FrazierAxel Bube

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Methods Mentioned

BETA
transmission electron microscopy
electron microscopy
light microscopy

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