PMID: 11317707Apr 25, 2001Paper

Inorganic fibres in the lung tissue of Hungarian and German lung cancer patients

International Archives of Occupational and Environmental Health
Klaus RödelspergerH J Woitowitz

Abstract

To ascertain the lung burden of asbestos fibres in Hungarian lung cancer patients in comparison with the cumulative asbestos exposure estimated from the occupational history. For 25 Hungarian lung cancer patients, lung tissue fibre analysis was performed by scanning transmission electron microscopy (STEM) and counting of ferruginous bodies (FBs) by light microscopy. Cumulative asbestos exposure in fibre-years was assessed from a standardised occupational history using the report "fibre years" of the German Berufsgenossenschaften. Median and maximum concentrations of fibres longer 5 microns per gram dry lung tissue (g dry) were 0.03 and 7.38 million fibres/g dry for chrysotile, 0.00 and 0.21 million fibres/g dry for amphibole and 0.22 and 0.62 million fibres/g dry for other mineral fibres (OMFs). The maximum values were observed in one patient for whom a high asbestos exposure was evident in advance from the occupational history. In comparison with reference values obtained by the same method for German patients with no indication of workplace asbestos exposure, increased concentrations of more than 0.2 million chrysotile fibres/g dry were obtained for six of the 25 Hungarian patients (24%). For one of them, the second highest e...Continue Reading

Citations

Mar 21, 2012·Inhalation Toxicology·David Villeda-CuevasFrancisco Arenas-Huertero
Sep 21, 2010·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Marcello LottiBruno Murer
Mar 20, 2009·American Journal of Industrial Medicine·Toomas UibuAntti Tossavainen
May 15, 2007·American Journal of Industrial Medicine·Rūta Petrauskaite EverattRemigijus Jankauskas

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