Inorganic Nanomaterials as Highly Efficient Inhibitors of Cellular Hepatic Fibrosis

ACS Applied Materials & Interfaces
Fei PengHan Kiat Ho

Abstract

Chronic liver dysfunction usually begins with hepatic fibrosis. To date, no effective anti-fibrotic drugs have been approved for clinical use in humans. In the current work, titanium dioxide (TiO2) nanoparticles (NPs) and silicon dioxide (SiO2) NPs are used as active inhibitors with intrinsic chemico-physico properties to block fibrosis and the associated phenotypes through acting on hepatic stellate cells (HSCs, the liver machinery for depositing scar tissues seen in fibrosis). Using LX-2 cells as the HSC model, internalized nanomaterials are found to suppress classical outcomes of cellular fibrosis, for example, inhibiting the expression of collagen I (Col-I) and alpha smooth muscle actin (α-SMA), initiated by transforming growth factor β (TGF-β)-activated HSCs in both a concentration-dependent and a time-dependent manner. Biochemically, these nanomaterials could also facilitate the proteolytic breakdown of collagen by up-regulation of matrix metalloproteinases (MMPs) and down-regulation of tissue inhibitors of MMPs (TIMPs). Furthermore, through regulating epithelial-mesenchymal transition (EMT) genes [e.g., E-cadherin (E-Cad) and N-cadherin (N-Cad)], the adhesion and migration profiles of TGF-β-activated LX-2 cells treated w...Continue Reading

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Citations

Sep 10, 2019·Chemical Society Reviews·Jie Kai TeeDavid Tai Leong
Jan 29, 2020·International Journal of Biological Macromolecules·Bo YangQun Wang
Jan 9, 2021·Advanced Drug Delivery Reviews·Xiao-Min LuoYing-Mei Feng
Jul 7, 2021·ACS Applied Materials & Interfaces·Xiaoyuan JiChunhai Fan

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