Inorganic nanovectors for nucleic acid delivery

Drug Delivery and Translational Research
Sandhya PranatharthiharanPadma V Devarajan

Abstract

Nucleic acids show immense potential to treat cancer, acquired immune deficiency syndrome, neurological diseases and other incurable human diseases. Upon systemic administration, they encounter a series of barriers and hence barely reach the site of action, the cell. Intracellular delivery of nucleic acids is facilitated by nanovectors, both viral and non-viral. A major advantage of non-viral vectors over viral vectors is safety. Nanovectors evaluated specifically for nucleic acid delivery include polyplexes, lipoplexes and other cationic carrier-based vectors. However, more recently there is an increased interest in inorganic nanovectors for nucleic acid delivery. Nevertheless, there is no comprehensive review on the subject. The present review would cover in detail specific properties and types of inorganic nanovectors, their preparation techniques and various biomedical applications as therapeutics, diagnostics and theranostics. Future prospects are also suggested.

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Citations

Nov 7, 2019·International Journal of Molecular Sciences·Suryaji PatilAi-Rong Qian
Feb 27, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Ya-Ping XiaoXiao-Qi Yu
Feb 17, 2019·European Journal of Drug Metabolism and Pharmacokinetics·Vinod S IparPadma V Devarajan
Dec 18, 2020·Frontiers in Bioengineering and Biotechnology·Benjamin GantenbeinDevina Purmessur

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