Inorganic-organic hybrid scaffolds for osteochondral regeneration

Journal of Biomedical Materials Research. Part a
Dany J Muñoz-PintoMariah S Hahn

Abstract

Ligament graft failure frequently results from poor integration of the replacement tissue with associated bone. Thus, the ability to regenerate the bone-ligament osteochondral interface would be advantageous in ligament reconstruction. At the osteochondral interface, the tissue transitions from a bone-like matrix to fibrocartilage. Therefore, a scaffold which promotes a spatially regulated transition in cell behavior from osteoblast-like to chondrocyte-like would be desirable. Previous research indicates that addition of inorganic components to organic scaffolds can enhance the deposition of bone-like matrix by associated osteoblasts. We therefore reasoned that a gradient in the inorganic content of a hybrid inorganic-organic scaffold may induce an osteochondral-like transition in cell phenotype and matrix production. To test this hypothesis, hydrogels were prepared from poly(ethylene glycol) (PEG) and star poly(dimethylsiloxane) (PDMS(star)). As anticipated, both the matrix deposition and phenotype of encapsulated osteoblasts varied with scaffold inorganic content, although the directionality of this modulation was contrary to expectation. Specifically, osteoblasts appeared to transdifferentiate into chondrocyte-like cells wit...Continue Reading

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Citations

Apr 23, 2010·Annals of Biomedical Engineering·Nathan H DormerMichael S Detamore
May 11, 2013·Journal of Materials Science. Materials in Medicine·Kyu-Oh KimIck-Soo Kim
Nov 26, 2010·Acta Biomaterialia·Xin QuMariah S Hahn
Jun 29, 2015·Materials Science & Engineering. C, Materials for Biological Applications·M CatauroP Mustarelli
Aug 18, 2012·Journal of Biomedical Materials Research. Part a·Dany J Munoz-PintoMariah S Hahn
Jan 13, 2015·Materials Science & Engineering. C, Materials for Biological Applications·M CatauroS Pacifico
Oct 25, 2014·Journal of Tissue Engineering·Seog-Jin SeoHae-Won Kim
Apr 11, 2018·Journal of Biomedical Materials Research. Part a·Tanmay P GharatMariah S Hahn
Dec 15, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Patricia Diaz-RodriguezMariah S Hahn
Jun 6, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Josh D Erndt-MarinoMariah S Hahn
Mar 6, 2021·ACS Biomaterials Science & Engineering·Felipe O BeltranMelissa A Grunlan
Jan 16, 2017·Acta Biomaterialia·Jingzhou YangAli Khademhosseini

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