Inorganic phosphate transporters in cancer: Functions, molecular mechanisms and possible clinical applications

Biochimica Et Biophysica Acta. Reviews on Cancer
Marco Antônio Lacerda-AbreuJosé Roberto Meyer-Fernandes

Abstract

Inorganic phosphate is one of the most essential nutrients for the maintenance of cell life. Because of its essential role in nutrient supplementation, the study of plasma membrane inorganic phosphate transporters in cancer biology has received much attention in recent years. Several studies suggest that these transporters are up-regulated in tumor cells and thus have been considered to be important promoters of tumor progression. Altered expression levels of inorganic phosphate transporters, such as NaPi-IIb (SLC34A2) and PiT-1 (SLC20A1), have been demonstrated. The purpose of this review article was to gather the relevant experimental records on inorganic phosphate transporters in tumors and to demonstrate the importance of these proteins in clinical applications. In this work, we demonstrate that for decades, the potential use of the inorganic phosphate transporter as an antigen for the diagnosis of tumor subtypes remained unknown. With the advancement in molecular biology techniques, phosphate transporters have been identified as being associated with cancer. In addition to their altered expression in cancer, several studies have demonstrated other functions of inorganic phosphate transporters, such as transceptors, rearran...Continue Reading

Citations

Aug 19, 2020·The FEBS Journal·Mattia D PizzagalliGiulio Superti-Furga
Dec 14, 2018·Pflügers Archiv : European journal of physiology·Eleanor Lederer, Carsten A Wagner
Jan 23, 2020·Journal of Bioenergetics and Biomembranes·Luiz Fernando Carvalho-KellyJosé Roberto Meyer-Fernandes
Nov 4, 2020·Cell Biology International·Marco A Lacerda-AbreuJosé R Meyer-Fernandes
Oct 4, 2020·Nutrients·Juan Serna, Clemens Bergwitz
Dec 10, 2020·International Journal of Molecular Sciences·Marco Antonio Lacerda-AbreuJose Roberto Meyer-Fernandes
Apr 14, 2021·Scientific Reports·Eva Maria Pastor-ArroyoCarsten A Wagner
Apr 15, 2021·Cell Biology International·Marco Antonio Lacerda-AbreuJosé Roberto Meyer-Fernandes
Aug 8, 2021·International Journal of Molecular Sciences·Marco Antonio Lacerda-Abreu, José Roberto Meyer-Fernandes

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