iNOS Gene Ablation Prevents Liver Fibrosis in Leptin-Deficient ob/ob Mice

Genes
Sara BecerrilGema Frühbeck

Abstract

iNOS deficiency in ob/ob mice improved liver inflammation and ECM remodeling-related genes, decreasing fibrosis, and metabolic dysfunction. The activation of iNOS by leptin is necessary for the synthesis and secretion of TNC in hepatocytes, suggesting an important role of this alarmin in the development of NAFLD.

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Citations

Jun 10, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Ramesh P ThylurRakesh K Srivastava
Apr 3, 2020·Journal of Physiology and Biochemistry·A RodríguezSara Becerril
Sep 11, 2019·Nutrients·Sara BecerrilGema Frühbeck

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Methods Mentioned

BETA
biopsies
ELISA
PCR

Software Mentioned

Primer Express
SPSS
ImageJ

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