PMID: 9436988Mar 14, 1998Paper

Inosine-5'-monophosphate dehydrogenase is a rate-determining factor for p53-dependent growth regulation

Molecular Biology of the Cell
Y LiuJames L. Sherley

Abstract

We have proposed that reduced activity of inosine-5'-monophosphate dehydrogenase (IMPD; IMP:NAD oxidoreductase, EC 1.2.1.14), the rate-limiting enzyme for guanine nucleotide biosynthesis, in response to wild-type p53 expression, is essential for p53-dependent growth suppression. A gene transfer strategy was used to demonstrate that under physiological conditions constitutive IMPD expression prevents p53-dependent growth suppression. In these studies, expression of bax and waf1, genes implicated in p53-dependent growth suppression in response to DNA damage, remains elevated in response to p53. These findings indicate that under physiological conditions IMPD is a rate-determining factor for p53-dependent growth regulation. In addition, they suggest that the impd gene may be epistatic to bax and waf1 in growth suppression. Because of the role of IMPD in the production and balance of GTP and ATP, essential nucleotides for signal transduction, these results suggest that p53 controls cell division signals by regulating purine ribonucleotide metabolism.

References

Jul 1, 1977·European Journal of Biochemistry·T J Franklin, P A Twose
Apr 15, 1992·European Journal of Biochemistry·M YamashitaY Nagahama
Jan 1, 1992·Advances in Enzyme Regulation·G WeberM Nagai
Jan 1, 1992·Cancer Investigation·W ZhenG Weber
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Nov 22, 1991·Science·S A Aaronson
Nov 1, 1991·Molecular and Cellular Biology·D A GlesneE Huberman
Jan 25, 1991·Cell·L C CantleyS Soltoff
May 10, 1991·Science·M I SimonN Gautam
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 1, 1990·Biochimica Et Biophysica Acta·A J Levine, J Momand
Jul 30, 1985·Biochimica Et Biophysica Acta·H E GruberJ E Seegmiller
Sep 1, 1987·Molecular and Cellular Biology·F R Collart, E Huberman
Jan 1, 1985·Current Topics in Cellular Regulation·M L Pall
Apr 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D G StreeterL N Simon
Jan 1, 1981·International Review of Cytology·S J HochhauserG S Stein
Feb 1, 1983·Molecular and Cellular Biology·H Okayama, P Berg
Feb 24, 1995·Cell·E M MiyashitaD A Thorley-Lawson
Oct 12, 1995·Nature·J BrugarolasG J Hannon
Oct 6, 1995·Science·C M KnudsonS J Korsmeyer
Jan 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·J L SherleyD R Johnson

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Citations

Sep 25, 2002·Bioorganic & Medicinal Chemistry Letters·Edwin J IwanowiczDiane L Hollenbaugh
Jun 2, 2009·Chemical Reviews·Lizbeth Hedstrom
Jun 24, 2010·The Journal of Pharmacology and Experimental Therapeutics·John HinesCraig M Crews
Aug 15, 2003·Molecular and Cellular Biology·Mafalda Escobar-HenriquesBertrand Daignan-Fornier
Jan 1, 2011·Journal of Biomedicine & Biotechnology·Jean-François Paré, James L Sherley
Jul 16, 2004·Kidney International·Pierre C Dagher
Jan 9, 2004·International Journal of Cancer. Journal International Du Cancer·Elisa MessinaAlessandro Giacomello
Sep 10, 2011·Stem Cells·Yang Hoon Huh, James L Sherley
Apr 23, 2014·Journal of Viral Hepatitis·L RonzoniM D Cappellini
Feb 4, 2012·Biochemical and Biophysical Research Communications·Hwa-Ryeon KimHong-Duk Youn
Mar 15, 2011·Toxicology and Applied Pharmacology·Azadeh MeshkiniKazem Nouri
Jul 27, 1999·Proceedings of the Association of American Physicians·S A Metz, A Kowluru
Nov 7, 2001·The Journal of Clinical Investigation·K J KellyP C Dagher
Jul 31, 2003·Biotechnology and Bioengineering·Hsuan-Shu LeeJames L Sherley
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R J DonahueT B Knudsen
Oct 18, 2000·The Journal of Biological Chemistry·M Escobar-Henriques, B Daignan-Fornier
Nov 8, 2001·American Journal of Physiology. Cell Physiology·T D BatiukP C Dagher
Sep 26, 2000·American Journal of Physiology. Cell Physiology·P C Dagher
Nov 4, 2020·Archives of Insect Biochemistry and Physiology·Dana MentItamar Glazer
Jul 20, 2001·Journal of the American Society of Nephrology : JASN·Jerome SampolRegis Guieu

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