Inosine may be an endogenous ligand for benzodiazepine receptors on cultured spinal neurons

Science
J F MacDonaldP Skolnick

Abstract

Mouse spinal neurons grown in tissue culture were used to study the membrane effects of the benzodiazepine flurazepam and the naturally occurring purine nucleoside inosine, which competes for benzodiazepine receptor sites in the central nervous system. Application of inosine elicited two types of transmitter-like membrane effects: a rapidly desensitizing excitatory response and a nondesensitizing inhibitory response. Flurazepam produced a similar excitatory response which showed cross-desensitization with the purine excitation. Flurazepam also blocked the inhibitory inosine response. The results provide electrophysiological evidence that an endogenous purine can activate two different conductances on spinal neurons and that flurazepam can activate one of the conductances and antagonize the other.

References

Aug 1, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·P Polc, W Haefely
Oct 20, 1977·Nature·C BraestrupR F Squires
Nov 9, 1978·Life Sciences·M J WilliamsonP Skolnick
Apr 25, 1975·Brain Research·G K KostopoulosJ W Phillis
Jan 1, 1975·European Journal of Pharmacology·J W PhillisJ J Limacher
Aug 15, 1975·Life Sciences·P V Sulakhe, J W Phillis
Feb 1, 1978·Canadian Journal of Physiology and Pharmacology·J F MacDonald, M S Berry
Apr 1, 1978·European Journal of Pharmacology·C Braestrup, R F Squires
Jul 1, 1978·The Journal of Physiology·J L Barker, B R Ransom
Oct 12, 1978·Nature·M J WilliamsonP Skolnick
Jun 1, 1977·Experimental Neurology·G K Kostopoulos, J W Phillis
Apr 21, 1977·Nature·R F Squires, C Brastrup
Oct 6, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·P Wolf, H L Haas
Oct 1, 1976·Life Sciences·J W Phillis, J P Edstrom
Dec 17, 1976·Brain Research·D R CurtisS J Brand
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·P PolcW Haefely
Jun 15, 1973·Nature·E M Silinsky, J I Hubbard
Dec 1, 1974·Canadian Journal of Physiology and Pharmacology·J W PhillisJ J Limacher
Jan 1, 1967·Advances in Pharmacology·G Zbinden, L O Randall
Jan 1, 1971·Journal of Neurophysiology·H Wachtel, E R Kandel

❮ Previous
Next ❯

Citations

Jan 1, 1984·Acta Biotheoretica·S C Brooks
Jan 1, 1981·Psychopharmacology·P J MarangosP Skolnick
Apr 1, 1983·Biochemical Pharmacology·J R HammondA S Clanachan
Nov 1, 1987·Biochemical Pharmacology·J P FryI L Martin
Oct 17, 1980·European Journal of Pharmacology·P SkolnickK Irmscher
Jun 10, 1981·European Journal of Pharmacology·P J Syapin, D W Rickman
May 18, 1984·European Journal of Pharmacology·J H Skerritt, R L Macdonald
Sep 24, 1979·Life Sciences·P J MarangosP Skolnick
Jun 1, 1981·Pharmacology, Biochemistry, and Behavior·L G DavisD Reker
Jan 1, 1986·Pharmacology, Biochemistry, and Behavior·J M Witkin, J E Barrett
Apr 1, 1986·Pharmacology, Biochemistry, and Behavior·J M WitkinP Larscheid
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·R A Shephard
Jul 1, 1981·Brain Research·C R Walker, J H Peacock
Jan 1, 1988·Neurochemistry International·A L Gundlach, G A Johnston
Dec 23, 1982·Neuroscience Letters·J H SkerrittL P Davies
Dec 30, 1983·Neuroscience Letters·J A Wagner, R J Katz
Jan 1, 1981·Medicinal Research Reviews·P Skolnick, S M Paul
Jun 1, 1981·British Journal of Pharmacology·M H Jensen
Jul 2, 1982·Science·A S Levine, J E Morley
Jan 18, 1980·Science·J F TallmanD W Gallager

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.