Inosine reduces microcirculatory disturbance and inflammatory organ damage in experimental acute pancreatitis in rats

American Journal of Surgery
Lutz SchneiderJ Werner

Abstract

Despite improvement in the management of severe necrotizing pancreatitis, mortality remains high. Today, no specific treatment exists. Inflammatory cascades and microcirculatory disturbances play a key role in the pathogenesis of acute pancreatitis. The aim of the present study was to evaluate the effects of inosine, an immunomodulatory substance, on the severity of experimental necrotizing pancreatitis. Severe necrotizing pancreatitis was induced in rats. Treatment groups received inosine either prophylactically or therapeutically. Pancreatic injury was evaluated by microcirculatory assessment and histology. Prophylactic inosine significantly attenuated pancreatic microcirculatory disturbances and morphologic injury in necrotizing pancreatitis. However, inosine treatment did not have any beneficial effects when applied therapeutically several hours after onset of the disease. Prophylactic inosine reduces microcirculatory and pancreatic injury in acute necrotizing pancreatitis. These effects should be assessed in the clinical setting of ERCP and pancreas transplantation.

References

Jan 1, 1992·Annals of Surgery·J SchmidtA L Warshaw
Nov 1, 1989·Pflügers Archiv : European journal of physiology·B F BeckerE Gerlach
Jan 15, 1987·The New England Journal of Medicine·M L Steer, J Meldolesi
Nov 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B N AmesP Hochstein
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·D C HooperH Koprowski
Oct 12, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·G HaskóC Szabó
May 25, 2001·Critical Care Medicine·F Garcia SorianoC Szabó
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·L LiaudetC Szabó
Jul 19, 2002·Biochemical Pharmacology·Emanuela MazzonSalvatore Cuzzocrea
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·J G MableyA L Salzman
May 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Tobias KeckErnst Klar

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Citations

Oct 13, 2010·Infectious Disease Clinics of North America·Lutz SchneiderJens Werner
Aug 18, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lutz SchneiderJens Werner
May 12, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T MüllerM Idzko
Jul 30, 2014·Molecular Neurobiology·Francisney Pinto NascimentoAdair Roberto Soares Santos
Feb 26, 2015·Life Sciences·Lutz SchneiderJens Werner
Oct 25, 2008·Shock·Satoshi HagiwaraTakayuki Noguchi

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