Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial

JAMA Neurology
Michael A SchwarzschildKen Eaton

Abstract

Convergent biological, epidemiological, and clinical data identified urate elevation as a candidate strategy for slowing disability progression in Parkinson disease (PD). To determine the safety, tolerability, and urate-elevating capability of the urate precursor inosine in early PD and to assess its suitability and potential design features for a disease-modification trial. The Safety of Urate Elevation in PD (SURE-PD) study, a randomized, double-blind, placebo-controlled, dose-ranging trial of inosine, enrolled participants from 2009 to 2011 and followed them for up to 25 months at outpatient visits to 17 credentialed clinical study sites of the Parkinson Study Group across the United States. Seventy-five consenting adults (mean age, 62 years; 55% women) with early PD not yet requiring symptomatic treatment and a serum urate concentration less than 6 mg/dL (the approximate population median) were enrolled. Participants were randomized to 1 of 3 treatment arms: placebo or inosine titrated to produce mild (6.1-7.0 mg/dL) or moderate (7.1-8.0 mg/dL) serum urate elevation using 500-mg capsules taken orally up to 2 capsules 3 times per day. They were followed for up to 24 months (median, 18 months) while receiving the study drug p...Continue Reading

Associated Clinical Trials

Feb 2, 2009·Michael Schwarzschild, Michael Schwarzschild
Nov 11, 2014·Sabrina Paganoni, M.D., Sabrina Paganoni, M.D.
Nov 25, 2015·Michael Alan Schwarzschild, Michael Alan Schwarzschild
Dec 30, 2015·Michael Alan SchwarzschildMichael Alan Schwarzschild
May 30, 2017·Sabrina Paganoni, M.D., Sabrina Paganoni, M.D.

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