Inositol 1,4,5-trisphosphate in blood and skeletal muscle in human malignant hyperthermia

British Journal of Anaesthesia
F WapplerJ Schulte am Esch

Abstract

The in vitro contracture test (IVCT) is the only available diagnostic method at present for evaluation of malignant hyperthermia (MH) susceptibility. However, the disadvantage of the IVCT is that it is invasive. Several studies suggest that an altered inositol phosphate system is involved in the development of MH. A greater concentration of inositol 1,4,5-trisphosphate (1,4,5-IP3) was found in MH susceptible (MHS) than in normal (MHN) skeletal muscles. In this study the concentrations of 1,4,5-IP3 in blood samples and skeletal muscle specimens of identical patients were measured in an attempt to define susceptibility to MH. Muscle biopsies were obtained from 34 patients with clinical suspicion of MH. Patients were first classified as MHS (n = 19), MHN (n = 8) or MH equivocal (MHE; n = 7) by the standard IVCT. For detection of 1,4,5-IP3 concentrations, blood samples were obtained and an additional muscle specimen was excised. After sample preparation, concentrations of 1,4,5-IP3 were measured using radioimmunoassay. In blood samples, concentrations of 1,4,5-IP3 were similar in all individuals tested for MH susceptibility and in control patients not tested for MH susceptibility (n = 44). In skeletal muscle, 1,4,5-IP3 concentratio...Continue Reading

Citations

Aug 2, 2002·Clinical Neuropharmacology·Ronald J Gurrera
Sep 21, 2016·Scientific Reports·Kerstin HoppeWerner Klingler
Aug 24, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C ZheyuY Lunan
Jun 9, 1999·Anesthesiology·F WapplerJ Schulte am Esch
Jul 27, 2000·Anesthesia and Analgesia·A Kudoh, A Matsuki
Oct 3, 2006·Current Opinion in Anaesthesiology·P J Adnet, G A Gronert
Apr 11, 2019·Biofouling·Dinis Reis OliveiraLena Granhag
Sep 13, 2001·European Journal of Anaesthesiology·F Wappler

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