Inositol 1,4,5 trisphosphate (IP3) receptor

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
Katsuhiko Mikoshiba

Abstract

The intensive molecular and biochemical study of IP(3)R has made great progress in elucidating the following unique properties of IP(3)R: 1) IP(3) dependent Ca(2+) release is quantal in nature; 2) IP(3)R allosterically and dynamically changes its form; 3) IP(3)R is functional even though it is fragmented by proteases into several pieces; 4) IP(3)R forms a functional association with a variety of molecules inside the cell, and with the channels on the plasma membrane; 5) the extremely high IP(3) binding affinity (500 approximately 1000 times higher than the original IP(3)R) sequence in the IP(3) binding region is covered with a suppressor sequence at the N-terminal. In parallel with these biochemical studies, studies on the role of IP(3)R during development have greatly advanced. Since IP(3)R was identified as a developmentally regulated phospho-glycoprotein, the Ca(2+) channel P400, it has diverse but essential functions in development and normal cell function.

References

Dec 26, 2001·Science's STKE : Signal Transduction Knowledge Environment·K Mikoshiba, M Hattori

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