PMID: 11920729Mar 29, 2002Paper

Inositol 1,4,5-trisphosphate transduction cascade in taste reception of the fleshfly, Boettcherisca peregrina

Journal of Neurobiology
Masayuki Koganezawa, I SHIMADA

Abstract

The role of an inositol 1,4,5-trisphosphate (IP3)-mediated transduction cascade in the response of taste receptor cells of the fleshfly Boettcherisca peregrina was investigated by using the following reagents: neomycin (an inhibitor of IP3 production), U73122 (an inhibitor of phospholipase C), adenophostin A (an agonist of the IP3-gated channel), IP3, ruthenium red (a blocker of the IP3-gated channel), and 2-aminoethoxydiphenylborate (2-APB; an antagonist of the IP3-gated channel). For introduction into the receptor cell, the reagents were mixed with a detergent, deoxycholate (DOC). After treatment with neomycin + DOC or U73122 + DOC, the response of the sugar receptor cell to sugars was depressed compared with responses after treatment with DOC alone. During the treatment of adenophostin A + DOC, the response of the sugar receptor cell was elicited. After treatment with IP3 + DOC, the response of the sugar receptor cell to sugars and to amino acids was apparently enhanced. When taste stimuli were administered in the presence of ruthenium red or 2-APB, the response of the sugar receptor cell to glucose were inhibited. The expression of genes for substances involved in the IP3 transduction cascade, such as G protein alpha subuni...Continue Reading

References

Nov 1, 1992·The Journal of General Physiology·T A GilbertsonS D Roper
May 11, 1992·The Journal of Membrane Biology·T MiyamotoJ H Teeter
Jun 15, 1992·Annals of Internal Medicine·C J BagatellW J Bremner
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·L HymelH Schindler
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G LoweG H Gold
Apr 16, 1985·Biochemical and Biophysical Research Communications·I N PessahJ E Casida
Feb 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·M Stengl
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·H Hatt, B W Ache
Mar 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·J Riesgo-EscovarJ R Carlson
Jan 28, 1994·Cell·C A Janeway, K Bottomly
Feb 1, 1994·Journal of Neurophysiology·Y OkadaD Restrepo
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·S TalluriD P Smith
Jun 27, 1996·Nature·G T WongR F Margolskee
Jul 1, 1996·Physiological Reviews·B Lindemann
Jun 20, 1997·Journal of Neurobiology·T Awasaki, K Kimura

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Citations

Oct 14, 2010·Chemical Senses·Nico BredendiekEva M Neuhaus
Jun 1, 2011·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Hideko KanTaisaku Amakawa
Apr 27, 2010·Journal of Insect Physiology·Patrick T BrownRichard I Woodruff
Apr 28, 2009·International Journal for Parasitology·Marthe H R LudtmannAnthony J Walker
Mar 12, 2009·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Qin OuyangTadashi Nakamura
Aug 27, 2005·The EMBO Journal·Hiroshi IshimotoTeiichi Tanimura
Dec 3, 2008·The European Journal of Neuroscience·Kohei Ueno, Yoshiaki Kidokoro
Nov 27, 2007·Journal of Insect Physiology·Maciej A PszczolkowskiSonny B Ramaswamy
Dec 3, 2003·British Journal of Pharmacology·Cristina ZorattiWolfgang F Graier
Apr 12, 2005·Journal of Cardiovascular Pharmacology·Dijle Kipmen-KorgunWolfgang F Graier
Mar 17, 2006·Journal of Neurogenetics·Kazue Usui-AokiDaisuke Yamamoto
Mar 21, 2021·Insect Biochemistry and Molecular Biology·Abhishek Ojha, Wenqing Zhang

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