PMID: 5908969Jan 7, 1966

Inositol deficiency resulting in death: an explanation of its occurrence in Neurospora crassa

Science
P Matile

Abstract

The incorporation of radio-active inositol and choline into the cytoplasmzic membranes of inositol-and choline-auxotrophic mnutants of Neuros-pora crassa revealed that the membrane of particles which contain proteases is relatively poor in lecithin and rich in inositol-phospholipid. In mycelia of the mutant requiring inositol, grown in a suboptimum amount of exogenous inositol, the strlctural initegrity of the protease particles is lost, and the bulk of intracellular protease activity is recovered in the soluble fraction of the cell. Death from this kind of inositol deficiency is interpreted as autolysis of the cytoplasm cautsed by free proteases.

Citations

Feb 1, 1983·Archives of Microbiology·C GabrielidesW A Scott
Sep 14, 1982·Biochimica Et Biophysica Acta·C GabrielidesW A Scott
May 30, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·L M LewinE Lepkifker
Apr 1, 1978·Mechanisms of Ageing and Development·R S Rana, K D Munkres
Jan 1, 1976·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·V A RasskazovV V Galkin
Oct 1, 1980·European Journal of Biochemistry·L KovácV Kovácová
Mar 25, 1975·Biochimica Et Biophysica Acta·R H Michell
Oct 14, 1982·Biochimica Et Biophysica Acta·M T McCammon, L W Parks
Dec 12, 1967·Journal of Ultrastructure Research·R M Thornton
Aug 1, 2013·Physiological Reviews·Tamas Balla
Jan 1, 1978·Zeitschrift für allgemeine Mikrobiologie·K H Riemay, R Tröger

Related Concepts

Carbon Isotopes
Choline Hydroxide
Protoplasm
Inositol
Neurospora
Peptide Hydrolases
Phosphatidylcholines
Nuclear Track Detection

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