Inositol polyphosphate 1-phosphatase is a novel antihypertrophic factor.

The Journal of Biological Chemistry
E A WoodcockRoss D Hannan

Abstract

Activation of G(q)-coupled alpha(1)-adrenergic receptors leads to hypertrophic growth of neonatal rat ventricular cardiomyocytes that is associated with increased expression of hypertrophy-related genes, including atrial natriuretic peptide (ANP) and myosin light chain-2 (MLC), as well as increased ribosome synthesis. The role of inositol phosphates in signaling pathways involved in these changes in gene expression was examined by overexpressing inositol phosphate-metabolizing enzymes and determining effects on ANP, MLC, and 45 S ribosomal gene expression following co-transfection of appropriate reporter gene constructs. Overexpression of enzymes that metabolize inositol 1,4,5-trisphosphate did not reduce ANP or MLC responses, but overexpression of the enzyme primarily responsible for metabolism of inositol 4,5-bisphosphate (Ins(1,4)P(2)), inositol polyphosphate 1-phosphatase (INPP), reduced ANP and MLC responses associated with alpha(1)-adrenergic receptor-mediated hypertrophy. Similarly overexpressed INPP reduced ANP and MLC responses associated with contraction-induced hypertrophy. In addition, overexpression of INPP reduced the increase in ribosomal DNA transcription associated with both hypertrophic models. Hypertrophied c...Continue Reading

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Citations

May 24, 2005·Pharmacology & Therapeutics·Elizabeth A Woodcock, Scot J Matkovich
Jan 6, 2010·European Heart Journal·Suree LekawanvijitHenry Krum
Jan 1, 2005·Current Opinion in Oncology·Olga Frankfurt, Steven T Rosen
Aug 1, 2006·Journal of Hypertension·Xiao-Ming GaoXiao-Jun Du
May 31, 2013·Journal of Cardiovascular Pharmacology·Zhen-hui ZhangShi-ming Liu
Apr 24, 2004·Transfusion·George B SchreiberUNKNOWN Retrovirus Epidemiology Donor Study
May 7, 2009·Annals of the New York Academy of Sciences·Michelle L HallsRoger J Summers
Jul 6, 2016·Clinical and Experimental Pharmacology & Physiology·Chung H ChuoBing H Wang
Jan 20, 2017·International Heart Journal·Dan WangHaiyun Jing
Jul 2, 2003·FEBS Letters·Elizabeth A WoodcockTrevor J Biden
Feb 5, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Arintaya PhrommintikulHenry Krum
Jan 6, 2007·Endocrinology·Xiao-lei MooreXiao-Jun Du
May 23, 2003·The Journal of Biological Chemistry·Christopher L AntosEric N Olson
Apr 22, 2015·Physiological Reports·Indrajeetsinh RanaFadi J Charchar

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