PMID: 2117207Jan 1, 1990Paper

Inositol supplementation in respiratory distress syndrome

Lung
M HallmanK Bry

Abstract

According to preliminary results inositol (INO) is an important nutrient to immature preterm infants (J Pediatr 1987; 110:604). However, it is absent in nutrition of critically ill very low birth weight infants. In a present randomized double blind trial INO or glucose (70-100 mg/kg/day) was given to altogether 230 preterm infants (gestation 24 to 31 w, mean 27.8 w, mean BW 1,106 g) with RDS during 5 neonatal days. Two more courses during the first month were given, if the infant remained respirator-dependent and did not tolerate breast milk. INO-supplemented infants tended to have a milder respiratory course during the first week than those on glucose. The surviving INO-treated infants had a lower incidence of bronchopulmonary dysplasia (BPD) than the controls (p less than 0.01). No infant receiving INO had severe retinopathy (gr 4), whereas of the surviving placebo treated infants 8.8% became blind (p less than 0.005). Inositol promotes endothelial cell growth, enhances glucocorticoid-mediated lung epithelial cell differentiation, and may serve as an antioxidant. INO should be seriously considered as a nutrient during compromised neonatal transition of very low birth weight infants.

References

May 1, 1986·Journal of Pediatric Gastroenterology and Nutrition·P Bromberger, M Hallman
Jul 1, 1987·The American Journal of Clinical Nutrition·S J Fomon
Jan 1, 1986·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·F L KretzerH M Hittner
Nov 1, 1986·Archives of Disease in Childhood·M HallmanM Pohjavuori
Jan 1, 1986·Annual Review of Cell Biology·U Kikkawa, Y Nishizuka

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Citations

May 7, 1992·The New England Journal of Medicine·M HallmanM Pohjavuori
Nov 26, 2015·Clinics in Perinatology·Brenda B Poindexter, Camilia R Martin
Aug 25, 2004·Clinics in Perinatology·Namasivayam Ambalavanan, Waldemar A Carlo
Jun 29, 2016·Expert Opinion on Drug Metabolism & Toxicology·Mariano BizzarriArturo Bevilacqua
Oct 26, 2018·JAMA : the Journal of the American Medical Association·Dale L PhelpsUNKNOWN Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network
Aug 7, 2019·Expert Opinion on Drug Metabolism & Toxicology·Simone GarzonGiovanni Monastra
Jul 10, 2019·The Cochrane Database of Systematic Reviews·Alexandra HowlettNishad Plakkal
Mar 10, 2012·American Journal of Respiratory Cell and Molecular Biology·Stefanie PreussMartin F Krause
May 1, 2015·The Cochrane Database of Systematic Reviews·Alexandra HowlettNishad Plakkal

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