PMID: 8608601Feb 9, 1996Paper

Inositol trisphosphate and cyclic ADP-ribose-mediated release of Ca2+ from single isolated pancreatic zymogen granules

Cell
O V GerasimenkoO H Petersen

Abstract

In pancreatic acinar cells low (physiological) agonist concentrations evoke cytosolic Ca2+ spikes specifically in the apical secretory pole that contains a high density of secretory (zymogen) granules (ZGs). Inositol 1,4,5-trisphosphate (IP3) is believed to release Ca2+ from the endoplasmic reticulum, but we have now tested whether the Ca(2+)-releasing messengers IP3 and cyclic ADP-ribose (cADPr) can liberate Ca2+ from AGs. In experiments on single isolated ZGs, we show using confocal microscopy that IP3 and cADPr evoke a marked decrease in the free intragranular Ca2+ concentration. Using a novel high resolution method, we have measured changes in the Ca2+ concentration in the vicinity of an isolated AG and show that IP3 and cADPr cause rapid Ca2+ release from the granule, explaining the agonist-evoked cytosolic Ca2+ rise in the secretory pole.

References

Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·O ThastrupA P Dawson
Oct 1, 1989·Pflügers Archiv : European journal of physiology·C M FullerI Schulz
Feb 26, 1987·Biochimica Et Biophysica Acta·J RogersD B McKay
Jan 1, 1984·The Journal of Membrane Biology·H StrebI Schulz
Aug 1, 1984·Pflügers Archiv : European journal of physiology·I NakagakiY Imai
Jan 27, 1995·Cell·D E Clapham
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·F W TseB Hille
Jan 1, 1994·Annual Review of Physiology·O H PetersenH Kasai
Jul 1, 1994·Physiological Reviews·T PozzanJ Meldolesi
Jun 1, 1994·Pflügers Archiv : European journal of physiology·E C Toescu, O H Petersen
Jan 28, 1993·Nature·M J Berridge
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A M Hofer, T E Machen

❮ Previous
Next ❯

Citations

Feb 14, 1998·Journal of Cellular Physiology·T TakeoM Wakui
Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·O H PetersenA V Tepikin
Sep 25, 1999·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·F W Tse, A Tse
May 9, 2000·Biochemical and Biophysical Research Communications·C Camello-AlmarazP J Camello
Dec 5, 1997·Cell Biochemistry and Biophysics·H C Lee
Nov 4, 2010·Cellular and Molecular Neurobiology·Seung Hyun YooYong Suk Hur
Nov 23, 2010·Cellular and Molecular Neurobiology·Jaime SantoDomingoJavier Alvarez
Dec 1, 2006·Journal of Mammary Gland Biology and Neoplasia·James L McManamanEdwin C Thrower
Jan 25, 2003·Cell Calcium·O V GerasimenkoO H Petersen
Apr 19, 2002·Progress in Neurobiology·Christof ZittAndreas Lückhoff
May 24, 2000·Cellular Signalling·S Shimura
Jan 29, 2002·Cellular Signalling·Barbara Wäsle, J Michael Edwardson
Nov 15, 2002·The European Journal of Neuroscience·Ricardo RigualJavier Alvarez
Jun 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Julia V GerasimenkoOle H Petersen
Mar 26, 2011·Proceedings of the National Academy of Sciences of the United States of America·Julia V GerasimenkoOleg V Gerasimenko
Jan 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guozhong HuangRoberto Docampo
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·M RaratyO H Petersen
Jun 17, 1998·Molecular Biology of the Cell·B S WilsonR J Wojcikiewicz
Oct 20, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Seung Hyun Yoo
Oct 29, 2010·Cold Spring Harbor Perspectives in Biology·Colin W Taylor, Stephen C Tovey
Jun 17, 2006·Acta Physiologica·A Verkhratsky
Jul 19, 2003·The Journal of Physiology·Ji-Bin PengMatthias A Hediger
Mar 27, 2001·Annual Review of Pharmacology and Toxicology·H C Lee
Sep 14, 2007·Annual Review of Physiology·Ole H Petersen, Alexei V Tepikin
Dec 16, 2003·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Robert SuttonOle H Petersen
Feb 3, 1998·American Journal of Respiratory Cell and Molecular Biology·M MaizieresJ Jacquot
Mar 22, 2014·Nature Reviews. Molecular Cell Biology·Robert A Cross, Andrew McAinsh
May 28, 2014·The Journal of General Physiology·James M McNallyJosé R Lemos
May 17, 2014·Cell Calcium·Julia GerasimenkoOleg Gerasimenko
Oct 5, 2011·Cellular and Molecular Life Sciences : CMLS·Enrico Zampese, Paola Pizzo
Mar 2, 2012·Expert Review of Gastroenterology & Hepatology·Oleg V GerasimenkoJulia V Gerasimenko

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell eTOC

Cell is a scientific journal publishing research across a broad range of disciplines within the life sciences field. Discover the latest research from Cell here.