Inositol trisphosphate independent increase of intracellular free calcium and amylase secretion in pancreatic acini.

Biochemical and Biophysical Research Communications
A K SalujaM L Steer

Abstract

It is generally believed that the activation of various cell surface receptors results in the phospholipase C-catalyzed production of inositol trisphosphate which, in turn, increases the intracellular concentration of free Ca2+ by stimulating its release from nonmitochondrial sources. We have investigated both the production of inositol trisphosphate and changes in intracellular Ca2+ concentration in rat pancreatic acini in response to caerulein and CCK-JMV-180, two analogs of cholecystokinin. Both of these analogs cause comparable increases in the rate of amylase secretion and in intracellular Ca2+ concentration but their effects on inositol phosphate generation are dramatically different; caerulein stimulates significant production of inositol phosphates within 1 min of its addition, whereas no detectable levels of inositol phosphates were generated within the same time after addition of CCK-JMV-180. These results suggest that the CCK-JMV-180 stimulated release of intracellular Ca2+ is not mediated by inositol trisphosphate but some other as yet unidentified messenger.

References

Aug 30, 1985·Biochemical and Biophysical Research Communications·R E PowersM L Steer
Mar 1, 1986·The American Journal of Physiology·A SalujaM L Steer
Jun 1, 1989·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J W PutneyO Thastrup
Jan 1, 1989·The Journal of Clinical Investigation·H Y GaisanoL J Miller
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·P VolpeD P Lew

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Citations

Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·K E Asin, L Bednarz
Aug 23, 1991·Biochimica Et Biophysica Acta·T F WalsethH C Lee
Aug 1, 1993·European Journal of Biochemistry·S Silvente-PoirotD Fourmy
Jun 25, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Anupriya SharmaGeorge Perides
Oct 29, 1993·Biochimica Et Biophysica Acta·Y Tsunoda

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