Inotropic drugs in acute circulatory failure

Intensive Care Medicine
P Herbert, J Tinker

Abstract

The use of inotropic drugs in patients requiring acute circulatory support is reviewed. A knowledge of their various peripheral effects is essential if the appropriate drug is to be used. The place or pressor amines, digitalis, salbutamol and glucagon in the treatment of patients with poor tissue perfusion is limited. Of the catecholamines, adrenaline causes excessive renal vasoconstriction and peripheral gangrene, noradrenaline increase myocardial work and diminishes peripheral perfusion and isoprenaline distributes blood away from the vital organs, namely: brain, kidneys, heart and mesentery. Dopamine is a useful agent as it enhances renal blood flow in low doses and is not excessively chronotropic. Dobutamine has not yet been shown to have significant advantages over other inotropes and requires further examination.

References

Jan 1, 1983·Intensive Care Medicine·C Blakeley, J Tinker
Jun 1, 1994·Intensive & Critical Care Nursing : the Official Journal of the British Association of Critical Care Nurses·C C Johnson
Mar 10, 2011·Journal of Cardiovascular Pharmacology·Timothy M Hoffman

Citations

Nov 1, 1977·Experimental Eye Research·L C Butterfield, A H Neufeld
May 1, 1977·British Heart Journal·J D StonerD C Harrison
Jul 1, 1977·British Heart Journal·P A Poole-WilsonB T Williams
Jan 4, 1979·The New England Journal of Medicine·E H SonnenblickT H LeJemtel
Jan 1, 1977·The Journal of Physiology·H Reuter, H Scholz
Apr 1, 1977·The American Journal of Cardiology·T A GillespieR Roberts
Aug 1, 1977·Intensive Care Medicine·B RegnierA Harari
May 1, 1975·The American Journal of Cardiology·E L HollowayD C Harrison
Jun 1, 1976·The American Journal of Cardiology·N Sperelakis, J A Schneider
Apr 15, 1972·Lancet·S LalV Soni
Mar 8, 1969·Lancet·E BroganD C Overy
Apr 1, 1972·Circulation·J S Karliner, E Braunwald
Dec 1, 1965·The American Journal of Cardiology·J T BotticelliR L Lange
Apr 1, 1971·The American Journal of Cardiology·E Braunwald
May 1, 1972·Circulation·R M Gunnar, H S Loeb
May 3, 1973·The New England Journal of Medicine·T W Smith
Apr 1, 1973·The American Journal of Cardiology·W E Shell, B E Sobel
Apr 1, 1973·The American Journal of Medicine·E J WinslowR M Gunnar
May 1, 1974·American Heart Journal·J BeregovichB Levitt
Jan 1, 1974·Cardiovascular Research·G Ross
May 1, 1974·Circulation Research·N W RobieJ L McNay
Jul 4, 1968·The New England Journal of Medicine·W W ParmleyE H Sonnenblick
Jul 1, 1971·Circulation·P W ArmstrongC A Sanders
Dec 1, 1970·The American Journal of Cardiology·L A Kuhn
Nov 1, 1969·Circulation·H S LoebR M Gunnar
Feb 1, 1970·American Heart Journal·H B BarnerG C Kaiser

Related Concepts

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