Inotropic effect of PGE1 and PGE2 on isolated rat atria. Influence of adrenergic mechanisms

Prostaglandins
L Sterin-BordaA L Gimeno

Abstract

The effects of a wide range of PGE1 and PGE2 concentrations on the isometric developed tension of isolated rat atria beating spontaneously or paced at a fixed rate, were explored. PGE1 only produced a negative inotropic effect (NIE), whereas PGE2 elicited a biphasic inotropic action; negative at low concentrations and positive (PIE) at higher ones. Phenoxybenzamine and phentolamine failed to modify either the NIE or the PIE, but subthreshold exogenous norepinephrine abolished the NIE, suggesting a presynaptic inhibitory effect of PGEs on the adrenergic neurotransmitter release. Auricles pretreated with subthreshold norepinephrine react with a PIE to PGE1, but not to PGE2. On the contrary in the presence of subthreshold methoxamine the PIE of PGE2 was increased whereas the action of PGE1 was not modified.

References

Jan 1, 1977·Annual Review of Pharmacology and Toxicology·P Hedqvist
Apr 1, 1974·Proceedings of the Society for Experimental Biology and Medicine·L S de BordaM F Gimeno
May 1, 1970·Acta Physiologica Scandinavica·P HedqvistA Wennmalm
May 1, 1972·Cardiovascular Research·D O Nutter, H J Crumly
Aug 15, 1970·Life Sciences. Pt. 1: Physiology and Pharmacology·A Wennmalm, P Hedqvist
Apr 1, 1971·Proceedings of the Society for Experimental Biology and Medicine·J V Levy, E Killebrew

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Citations

Jan 1, 1992·Basic Research in Cardiology·K Schrör, T Hohlfeld
Apr 1, 1986·Pharmacological Research Communications·L Canga, L Sterin-Borda
Jan 1, 1984·International Journal of Immunopharmacology·E BordaL Sterin-Borda
Jan 1, 1988·International Journal of Immunopharmacology·G A Cremaschi, L Sterin-Borda
Jan 1, 1990·International Journal of Immunopharmacology·M R FiniaszL Sterin-Borda
May 1, 1990·Clinical Immunology and Immunopathology·G GorelikE S Borda
Jun 1, 1981·Pharmacological Research Communications·L CangaA L Gimeno

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