PMID: 6440712Jan 1, 1984Paper

Inotropic effects of ionic contrast media: the role of calcium binding additives

Catheterization and Cardiovascular Diagnosis
D K MurdockP J Scanlon


Renografin-76 (RG76) regularly depresses myocardial contractility during coronary angiography. Angiovist-370 (AV370) is a contrast medium similar to RG76 except the calcium sequestering agents sodium citrate and EDTA in RG76 have been replaced by calcium EDTA (an additive that does not bind additional calcium). To determine if the calcium sequestering agents contribute to the mechanical depression produced by ionic contrast media, this study compared the inotropic response of RG76 to that of AV370. Additionally, saline solutions containing sodium citrate + EDTA and calcium EDTA at concentrations found in the respective contrast media were also compared. In 10 open chest dogs the percent change and duration of the inotropic response following intracoronary injections of RG76 and AV370, as well as solutions of sodium citrate + EDTA and calcium EDTA were compared using Walton-Brodie strain gauges. Injections, 2 cc, of RG76 and AV370 produced a biphasic response characterized by an initial negative inotropic response followed by a more prolonged positive inotropic response. The magnitude (67 +/- 3% vs 59 +/- 2%; p less than 0.001) and duration (34 +/- 3 vs 24 +/- 2 sec; p less than 0.001) of the initial negative inotropic response ...Continue Reading


May 1, 1978·Investigative Radiology·K R ThomsonH W Fischer
Sep 1, 1976·Investigative Radiology·R A Chahine, A E Raizner
Jul 1, 1975·Circulation·J B CaulfieldJ W Harthorne
Jun 2, 1966·The New England Journal of Medicine·A Benchimol, E M McNally
Dec 1, 1968·The Journal of General Physiology·L E Bailey, P E Dresel
Sep 1, 1982·Investigative Radiology·T W MorrisH W Fischer
Jun 1, 1983·Journal of the American College of Cardiology·G L Wolf, J W Hirshfeld
Jan 1, 1982·Cardiovascular and Interventional Radiology·J R SerurS Paulin
Nov 1, 1980·Investigative Radiology·H W Fischer, T W Morris
Oct 1, 1961·The American Journal of Physiology·W G NAYLER

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Oct 26, 1990·The American Journal of Cardiology·J W Hirshfeld
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