PMID: 8996633Nov 1, 1996Paper

Inotropic reserve and histological appearance of hibernating myocardium in conscious pigs with ameroid-induced coronary stenosis

Basic Research in Cardiology
Y T ShenS F Vatner

Abstract

Inotropic reserve, demonstrated with administration of sympathomimetic amines, is characteristic of hibernating myocardium. The goal of this study was to determine whether inotropic reserve was present following chronic coronary artery constriction in the pig, which is one potential model of hibernating myocardium. The effects of isoproterenol were examined in five conscious pigs 21 +/- 2.1 days after ameroid implantation on the left circumflex coronary artery on measurements of left ventricular (LV) pressure, LV dP/dt, and regional wall thickening in the ameroid-dependent zone (posterior wall) and contralateral non-ischemic zone (anterior wall). Isoproterenol, 0.1 microgram/kg/min, increased LV dP/dt by 96 +/- 11%, heart rate by 43 +/- 13 beats/min, and normalized systolic wall thickening, slightly, but not significantly more in the ameroid-dependent zone (+1.57 +/- 0.31 mm) than in the contralateral non-ischemic zone (+1.04 +/- 0.31 mm), although the baseline wall thickening was reduced significantly in the ameroid-dependent zone. This occurred at a time when baseline myocardial blood flow was preserved and myocardial perfusion in the ameroid-dependent zone was derived in part from the native coronary circulation and also thr...Continue Reading

References

Jan 1, 1989·Basic Research in Cardiology·F C WhiteC M Bloor
Jun 1, 1973·Beiträge Zur Pathologie·M De BrabanderF Verheyen
Feb 1, 1994·Journal of the American College of Cardiology·H K Hammond, M D McKirnan

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Citations

Nov 26, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Gerd HeuschShahbudin H Rahimtoola
Feb 23, 2000·Journal of Cardiovascular Pharmacology and Therapeutics·E R SchwarzP Hanrath
Jun 2, 2007·Heart Failure Reviews·Christophe Depre, Stephen F Vatner
Jul 17, 1998·The New England Journal of Medicine·W WijnsP G Camici
Oct 28, 1998·Physiological Reviews·G Heusch
Feb 4, 2021·Nature Reviews. Cardiology·Gerd Heusch
Jan 14, 2022·Basic Research in Cardiology·Gerd Heusch

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