Inotuzumab ozogamicin in the treatment of acute lymphoblastic leukemia

Expert Review of Hematology
Jenny DahlElias Jabbour

Abstract

Over 90% of leukemic blasts in patients with acute lymphoblastic leukemia express the marker CD22. Inotuzumab ozogamicin (INO) is a CD22-directed humanized monoclonal antibody conjugated to the potent cytotoxin, calicheamicin, via an acid labile linker. INO has shown high rates of response in the treatment of relapsed and refractory (R/R) ALL in single-agent studies, with fewer adverse effects than traditional cytotoxic chemotherapy. Given this experience, studies are now being done to evaluate INO in combination with low-intensity chemotherapy as frontline treatment for older adults with ALL and patients with R/R disease. Herein we will discuss the use of INO in the treatment of acute lymphoblastic leukemia.

References

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Citations

Apr 22, 2020·British Journal of Haematology·José L FusterUNKNOWN Leukemia Working Group of the Spanish Society of Pediatric Hematology, Oncology (SEHOP)
Aug 28, 2021·Biomedicines·Candice Maria Mckertish, Veysel Kayser

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