Inpatient epidemiology and economic burden of granulomatosis with polyangiitis: a 10-year study of the national inpatient sample.

Rheumatology
Patompong UngprasertPaul T Kroner

Abstract

To characterize inpatient epidemiology and economic burden of granulomatosis with polyangiitis (GPA). Patients with GPA were identified from the Nationwide Inpatient Sample (NIS), the largest inpatient database in the USA consisting of over 4000 non-federal acute care hospitals, using the ICD-9 CM code. A cohort of comparators without GPA was also constructed from the same database. Data on demographics, procedures, length of stay, mortality, morbidity and total hospitalization charges were extracted. All analysed data were extracted from the database for the years 2005-2014. The inpatient prevalence of GPA was 32.6 cases per 100 000 admissions. GPA itself (38.3%), pneumonia (13.7%) and sepsis (8.4%) were the most common reasons for admission. After adjusting for potential confounders, the all-cause mortality adjusted odds ratio (aOR) of patients with GPA was significantly higher than that of patients without GPA (aOR 1.20; 95% CI: 1.41, 1.61). This was also true for several morbidities, including acute kidney injury, multi-organ failure, shock and need for intensive care unit admission. Hospitalizations of patients with GPA were associated with higher cost as demonstrated by an adjusted additional mean of $5125 (95% CI: $4719,...Continue Reading

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Citations

Apr 17, 2020·Journal of Clinical Medicine·Charat ThongprayoonWisit Cheungpasitporn
Dec 15, 2020·Rheumatology and Therapy·Kirsi TaimenLaura Pirilä
Oct 13, 2021·Rheumatology International·Pratibha BanerjeeSabyasachi Senapati

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