Input to the lateral habenula from the basal ganglia is excitatory, aversive, and suppressed by serotonin.

Neuron
Steven J ShabelRoberto Malinow

Abstract

The lateral habenula (LHb) has recently been identified as a key regulator of the reward system by driving inhibition onto dopaminergic neurons. However, the nature and potential modulation of the major input to the LHb originating from the basal ganglia are poorly understood. Although the output of the basal ganglia is thought to be primarily inhibitory, here we show that transmission from the basal ganglia to the LHb is excitatory, glutamatergic, and suppressed by serotonin. Behaviorally, activation of this pathway is aversive, consistent with its role as an "antireward" signal. Our demonstration of an excitatory projection from the basal ganglia to the LHb explains how LHb-projecting basal ganglia neurons can have similar encoding properties as LHb neurons themselves. Our results also provide a link between antireward excitatory synapses and serotonin, a neuromodulator implicated in depression.

References

Oct 1, 1976·The Journal of Comparative Neurology·R KimM B Carpenter
Jun 3, 1982·Brain Research·S R VincentE G McGeer
Jan 1, 1996·Brain Research Bulletin·G FerraroV La Grutta
Apr 1, 1997·Current Opinion in Neurobiology·W Schultz
May 11, 2005·Neurobiology of Disease·Diane T StephensonMarina E Emborg
Aug 24, 2005·Nature Neuroscience·Edward S BoydenKarl Deisseroth
Jul 5, 2008·Neurobiology of Disease·Pedro Barroso-ChineaJosé L Lanciego
Nov 29, 2008·Neuron·Simon Hong, Okihide Hikosaka
Jun 19, 2010·Nature Reviews. Neuroscience·Okihide Hikosaka

❮ Previous
Next ❯

Citations

Oct 23, 2012·Anatomical Science International·Hidenori Aizawa
Jun 26, 2012·Nature Neuroscience·Alice M Stamatakis, Garret D Stuber
Sep 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Marcus Stephenson-JonesSten Grillner
Oct 9, 2012·Science·Olivier BertonMichael E Thase
Jan 17, 2014·Nature·Karl Deisseroth
Jul 30, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rebecca P LawsonJonathan P Roiser
Aug 27, 2014·Nature Neuroscience·Christophe D ProulxRoberto Malinow
Sep 23, 2014·Nature Neuroscience·David H RootMarisela Morales
Jan 19, 2016·Frontiers in Psychiatry·Nora L Salaberry, Jorge Mendoza
Jan 16, 2013·The Journal of Physiology·Sten GrillnerMarcus Stephenson-Jones
Jan 28, 2016·Nature Neuroscience·Garret D Stuber, Roy A Wise
Feb 13, 2015·Proceedings of the National Academy of Sciences of the United States of America·Benjamin D SachsMarc G Caron
Apr 4, 2013·Neuroscience and Biobehavioral Reviews·Carol A Seger, Erik J Peterson
Dec 1, 2015·Pharmacology & Therapeutics·Giuseppe Di Giovanni, Philippe De Deurwaerdère
Nov 7, 2015·Cellular and Molecular Life Sciences : CMLS·Dipesh ChaudhuryMing-Hu Han
Feb 18, 2016·Social Cognitive and Affective Neuroscience·Daniella J Furman, Ian H Gotlib
Oct 10, 2013·The European Journal of Neuroscience·Linda W M van KerkhofLouk J M J Vanderschuren
Apr 10, 2014·The European Journal of Neuroscience·Salvatore LeccaManuel Mameli
Aug 15, 2014·The Journal of Comparative Neurology·Jonas BromsInes Ibañez-Tallon
May 21, 2013·Genes, Brain, and Behavior·S LammelM R Warden
May 15, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Victor MathisLucas Lecourtier
Mar 31, 2016·Brain Structure & Function·Lara Eid, Martin Parent
Apr 2, 2016·Scientific Reports·Guiqin XieJiang-Hong Ye
Jan 1, 2016·Current Opinion in Behavioral Sciences·Avin Veerakumar, Olivier Berton
Jun 2, 2015·Frontiers in Systems Neuroscience·Dave J Hayes
Apr 25, 2015·Behavioural Brain Research·Satoshi IkemotoAaron Tan
Feb 5, 2013·Current Opinion in Neurobiology·Jonathan P Britt, Antonello Bonci

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.