PMID: 19943237Nov 28, 2009Paper

INR deviations in hemodialyzed patients under low dose oral anticoagulant therapy

The International Journal of Artificial Organs
Athina GompouB Agroyannis

Abstract

The aim of this retrospective study was to evaluate the International Normalized Ratio (INR) in hemodialyzed uremic patients under treatment with oral anticoagulation drugs. Eleven out of one hundred and forty-two uremic hemodialyzed patients in our unit were included in the study. These 11 patients aged from 70 to 85 (mean: 76 years) were under oral anticoagulation treatment for protection from thromboembolic events. They received 1 mg acenocumarol daily with the therapeutic goal of achieving an INR between 2 and 2.5 units. During the last year, the number of total INR determinations was 129. Based on the INR levels, measurements were classified into three categories of anticoagulation, termed "under-anticoagulation", "target-anticoagulation", and "over-anticoagulation". The number, the percentage, and the mean value (+/-SD) of INR measurements for each category, respectively, were under-anticoagulation: 39, 30%, 1.78 +/- 0.14; target-anticoagulation: 48, 37.5%, 2.20 +/- 0.14; and over-anticoagulation: 42, 32.5%, 3.14 +/- 0.64. The mean value +/-SD of all INR determinations (n=129) was 2.34 +/-0.65. No thromboembolic or major bleeding events occurred in our patients with these INR. In conclusion, in elderly, hemodialyzed uremi...Continue Reading

References

Feb 1, 2003·International Journal of Cardiology·Eduardo VázquezVicente Pérez
Jul 15, 2005·Kidney International·Farzad ZiaiMartin Haas
Sep 12, 2006·Journal of Thrombosis and Haemostasis : JTH·F DentaliM Crowther

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Citations

Jan 1, 2014·TheScientificWorldJournal·Marek SaracynStanisław Niemczyk

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