Insect cytokine growth-blocking peptide signaling cascades regulate two separate groups of target genes

The FEBS Journal
Yosuke NinomiyaY Hayakawa

Abstract

Growth-blocking peptide (GBP) is a 25 amino acid insect cytokine found in lepidopteran insects that has diverse biological activities, such as larval growth regulation, paralysis induction, cell proliferation, and stimulation of immune cells. GBP also enhances expression of the tyrosine hydroxylase (TH, EC 1.14.16.2) and 3,4-dihydroxy-l-phenylalanine (Dopa) decarboxylase (DDC, EC 4.1.1.26) genes, which elevate dopamine levels in insect epidermal cells. We used insect epidermis and cultured cells to define the role of the GBP signaling pathway in the enhancement of TH and DDC gene expression. It has been recently reported that robust expression of the DDC gene requires activation of extracellular signal-regulated kinase (ERK) in epidermal cells of wounded Drosophila embryos. This study confirmed that GBP activates ERK, but this activation is not directly linked to the enhancement of TH and DDC gene expression. One of the GBP pathway components is phospholipase C, whose activation is essential for the activation of ERK and elevation of expression of both enzyme genes. The downstream signaling pathways diverge to ERK activation through activated protein kinase C and expression of the enzyme genes through inositol triphosphate rece...Continue Reading

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Citations

Aug 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yasunori OdaYoichi Hayakawa
Sep 16, 2011·The Journal of Biological Chemistry·Masasuke RyudaYoichi Hayakawa
Dec 27, 2011·Insect Biochemistry and Molecular Biology·Koichiro YamaguchiYoichi Hayakawa
Apr 23, 2013·Archives of Insect Biochemistry and Physiology·Shunsuke X FurihataYoichi Hayakawa
Dec 3, 2013·Journal of Insect Physiology·Hikaru KiyotakeYoichi Hayakawa
Nov 5, 2013·Journal of Invertebrate Pathology·Shunsuke FurihataYoichi Hayakawa
Apr 11, 2019·Frontiers in Physiology·Stephen B Shears, Yoichi Hayakawa
Dec 13, 2017·Proceedings of the National Academy of Sciences of the United States of America·Eui Jae SungYoichi Hayakawa

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