Insect cytokine paralytic peptide (PP) induces cellular and humoral immune responses in the silkworm Bombyx mori.

The Journal of Biological Chemistry
Kenichi IshiiKazuhisa Sekimizu

Abstract

In the blood (hemolymph) of the silkworm Bombyx mori, the insect cytokine paralytic peptide (PP) is converted from an inactive precursor to an active form in response to the cell wall components of microorganisms and contributes to silkworm resistance to infection. To investigate the molecular mechanism underlying the up-regulation of host resistance induced by PP, we performed an oligonucleotide microarray analysis on RNA of blood cells (hemocytes) and fat body tissues of silkworm larvae injected with active PP. Expression levels of a large number of immune-related genes increased rapidly within 3 h after injecting active PP, including phagocytosis-related genes such as tetraspanin E, actin A1, and ced-6 in hemocytes, and antimicrobial peptide genes cecropin A and moricin in the fat body. Active PP promoted in vitro and in vivo phagocytosis of Staphyloccocus aureus by the hemocytes. Moreover, active PP induced in vivo phosphorylation of p38 mitogen-activated protein kinase (p38 MAPK) in the fat body. Pretreatment of silkworm larvae with ML3403, a pharmacologic p38 MAPK inhibitor, suppressed the PP-dependent induction of cecropin A and moricin genes in the fat body. Injection of active PP delayed the killing of silkworm larvae ...Continue Reading

References

Oct 1, 1991·European Journal of Biochemistry·H G BomanD A Lidholm
Oct 10, 1995·Proceedings of the National Academy of Sciences of the United States of America·B LemaitreJ A Hoffmann
Jul 30, 1999·Developmental and Comparative Immunology·S NatoriA Kobayashi
Oct 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·M LagueuxJ A Hoffmann
Aug 4, 2001·Biochemical and Biophysical Research Communications·M KamimuraM Kiuchi
Dec 14, 2001·Proceedings of the National Academy of Sciences of the United States of America·P IrvingC Hetru
Jan 29, 2002·Nature Immunology·Jules A Hoffmann, Jean-Marc Reichhart
May 29, 2002·The EMBO Journal·Ennio De GregorioBruno Lemaitre
Jul 27, 2002·Science·Dennis H KimFrederick M Ausubel
Sep 13, 2002·Insect Biochemistry and Molecular Biology·M D Lavine, M R Strand
Nov 15, 2002·Developmental Cell·Michael BoutrosNorbert Perrimon
Mar 26, 2003·Archives of Insect Biochemistry and Physiology·Yuichi NakaharaManabu Kamimura
Sep 12, 2003·Developmental Cell·Hervé AgaisseNorbert Perrimon
Nov 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kazuei MitaSusumu Maeda
May 15, 2004·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Kazuei MitaTakuji Sasaki
Jun 18, 2004·Immunological Reviews·Lage Cerenius, Kenneth Söderhäll
Feb 1, 2005·Cellular Microbiology·Phil IrvingMarie Meister
Mar 22, 2005·Experimental Cell Research·Karin C JohanssonKenneth Söderhäll
Dec 13, 2005·PLoS Biology·Shannon L Stroschein-StevensonAlexander D Johnson
Dec 20, 2005·Insect Biochemistry and Molecular Biology·Yoshihiro FujiwaraKunihiro Shiomi
Mar 27, 2007·PLoS Pathogens·David S SchneiderMimi M Shirasu-Hiza
Jun 8, 2007·The Journal of Biological Chemistry·Shufei ZhuangMichael R Kanost
Jan 26, 2008·Nature Reviews. Immunology·Lynda M Stuart, R Alan Ezekowitz
Apr 9, 2008·Current Biology : CB·Nathalie PujolJonathan J Ewbank
May 3, 2008·BMB Reports·Kamna Aggarwal, Neal Silverman
Jul 16, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tajamul HussainKamal A Mohammed
Oct 7, 2008·Insect Biochemistry and Molecular Biology·Hiromitsu TanakaMinoru Yamakawa
Oct 9, 2008·Developmental and Comparative Immunology·Yuichi NakaharaManabu Kamimura
Sep 15, 2009·Cell Host & Microbe·Naoaki ShinzawaHirotaka Kanuka

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Citations

Sep 11, 2010·The Journal of Biological Chemistry·Yasushi KanamoriManabu Kamimura
Sep 23, 2011·The Journal of Biological Chemistry·Yuichi HanadaChikara Kaito
Feb 18, 2014·Journal of Invertebrate Pathology·Kenichi IshiiKazuhisa Sekimizu
Nov 28, 2012·Developmental and Comparative Immunology·Kenichi IshiiKazuhisa Sekimizu
May 15, 2012·Insect Biochemistry and Molecular Biology·Xiu-Zhen ShiXiao-Qiang Yu
Dec 21, 2010·Developmental and Comparative Immunology·Shu ZhangMichael R Strand
Feb 1, 2011·Drug Discoveries & Therapeutics·S DhitalK Sekimizu
Apr 15, 2016·Molecular Immunology·Xiaolong HuChengliang Gong
Feb 28, 2015·Developmental and Comparative Immunology·Dongran LiuChaoliang Liu
Apr 16, 2013·Toxicon : Official Journal of the International Society on Toxinology·Wafa BouzidAngélique Vétillard
Aug 11, 2016·Scientific Reports·Jin SuzukiMasahisa Watarai
Oct 13, 2017·Drug Discoveries & Therapeutics·Makoto UraiKazuhisa Sekimizu
Jan 24, 2014·Infection and Immunity·Kenichi IshiiKazuhisa Sekimizu
Dec 19, 2014·Archives of Insect Biochemistry and Physiology·Kenichi IshiiKazuhisa Sekimizu
Nov 27, 2018·Journal of Invertebrate Pathology·Qiuping GaoGuoqing Wei
Jan 1, 2018·Developmental and Comparative Immunology·Kangkang Chen, Zhiqiang Lu
Sep 8, 2021·Virulence·Atmika PaudelHideaki Higashi

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