PMID: 6539419Jun 1, 1984Paper

Insect radiosensitivity: dose curves and dose-fractionation studies of dominant lethal mutations in the mature sperm of 4 insect species

Mutation Research
L E LaChance, C K Graham

Abstract

Males of 4 species of insects: Musca domestica L. (housefly) (Diptera), Oncopeltus fasciatus (Dallas) ( milkweed bug) (Hemiptera), Anagasta kuhniella ( Zeller ) ( mealmouth ) (Lepidoptera) and Heliothis virescens (Fab.) (tobacco budworm ) (Lepidoptera) were irradiated as adults. Dose--response curves for the induction of dominant lethal mutations in the mature sperm were constructed. The curves were analyzed mathematically and compared with theoretical computer simulated curves requiring 1, 2, 4, 8 and 16 'hits' for the induction of a dominant lethal mutation. The 4 species belonging to 3 different orders of insects showed a wide range in radiation sensitivity and vastly different dose--response curves. The house fly was the most sensitive and displayed a '1-hit' curve. The milkweed bug was intermediate in sensitivity and the curve exhibited '4-hit' kinetics. The mealmoth and tobacco budworm were most radioresistant and the response curves resembled 8-16--hit simulated curves. When the data were analyzed by several mathematical models we found that a logistic response curve gave reasonably good fit with vastly different parameters for the 4 species. Dose-fractionation experiments showed no reduction in the frequency of lethal m...Continue Reading

Citations

Jun 8, 2002·Mutation Research·Alan S Robinson
Mar 7, 2009·Mutagenesis·I-Cheng ChengT C Wang
Apr 1, 1991·Medical and Veterinary Entomology·Y M Mansour, E S Krafsur
May 9, 2001·Genome Génome / Conseil National De Recherches Canada·A Tothová, F Marec
May 17, 2006·Malaria Journal·Michelle E H HelinskiBart G J Knols
Dec 16, 2009·Malaria Journal·Michelle E H HelinskiBart G J Knols
Dec 1, 1994·Environmental Health Perspectives·S L Anderson, G C Wild
Jun 19, 2004·International Journal of Radiation Biology·S ChandnaV Jain
Jun 11, 2011·The International Journal of Biochemistry & Cell Biology·Shubhankar SumanSudhir Chandna
Sep 30, 2016·Journal of the Royal Society, Interface·Thorin JonssonDaniel Robert

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