PMID: 8453162Mar 1, 1993Paper

Insect repellent (N,N-diethyl-m-toluamide) cardiovascular toxicity in an adult

The Annals of Pharmacotherapy
J R ClemM A Raebel

Abstract

To describe a case of N,N-diethyl-m-toluamide (DEET)-induced cardiovascular toxicity in an adult and reviews other cases that have been reported in the published literature. Human and animal data available on DEET pharmacokinetics are reviewed and factors that predispose an individual to DEET toxicity are identified. Case report information was obtained through personal contact with the patient during hospitalization and by telephone, and also from the patient's medical records. Computerized literature searches were conducted with the following systems to obtain medical literature on DEET toxicity: TOXLINE, International Pharmaceutical Abstracts, and MEDLINE. Index Medicus was searched manually. All reported cases of DEET toxicity in children and adults were reviewed. Case reports were evaluated for the quantity of the DEET exposure (topical or oral), the clinical manifestations of the exposure, and the outcome of the exposure. This case is similar in some aspects to those already in the literature; however, very few cases of DEET toxicity in adults have been reported. Cardiovascular toxicity in humans related to DEET application has not been previously reported in the published medical literature. DEET exposure (topical or ora...Continue Reading

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Citations

Jun 2, 2000·Seminars in Cutaneous Medicine and Surgery·J W Melski
Apr 14, 2005·Journal of the American Mosquito Control Association·Byeoung-Soo ParkSung-Eun Lee
Oct 28, 2006·Journal of the American Mosquito Control Association·Junwei ZhuAijun Zhang
Aug 8, 2014·PloS One·Daniel R SwaleJeffrey R Bloomquist
Nov 4, 2015·Journal of Parasitology Research·Jong Kwang YoonYoung Bong Kim
Dec 28, 1999·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·L C HampersJ B Leikin
Jan 1, 1997·Journal of Toxicology. Clinical Toxicology·T G Osimitz, J V Murphy
Mar 24, 2011·Cutaneous and Ocular Toxicology·Fatima Sasha Alikhan, Howard Maibach
Jan 27, 2016·The Journal of Dermatological Treatment·Jocelyn Rodriguez, Howard I Maibach
Jul 9, 2014·Journal of Analytical Toxicology·Devin WilesMarcel Casavant
Jul 14, 2010·Pest Management Science·Gretchen PaluchJoel Coats
Jul 11, 1998·Infectious Disease Clinics of North America·B U Samuel, M Barry
Jul 8, 2021·Environmental Science and Pollution Research International·Yasser El-Nahhal, Ibrahim El-Nahhal

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