Insecticides cause transcriptional alterations of endocrine related genes in the brain of honey bee foragers

Chemosphere
Karl FentVerena Christen

Abstract

Bees are exposed to endocrine active insecticides. Here we assessed expressional alteration of marker genes indicative of endocrine effects in the brain of honey bees. We exposed foragers to chlorpyrifos, cypermethrin and thiacloprid and assessed the expression of genes after exposure for 24 h, 48 h and 72 h. Chlorpyrifos caused the strongest expressional changes at 24 h characterized by induction of vitellogenin, major royal jelly protein (mrjp) 2 and 3, insulin-like peptide (ilp1), alpha-glucosidase (hbg3) and sima, and down-regulation of buffy. Cypermethrin caused minor induction of mrjp1, mrjp2, mmp1 and ilp1. The sima transcript showed down-regulation at 48 h and up-regulation at 72 h. Exposure to thiacloprid caused down-regulation of vitellogenin, mrjp1 and sima at 24 h, and hbg3 at 72 h, as well as induction of ilp1 at 48 h. The buffy transcript was down-regulated at 24 h and up-regulated at 48 h. Despite compound-specific expression patterns, each insecticide altered the expression of some of the suggested endocrine system related genes. Our study suggests that expressional changes of genes prominently expressed in nurse or forager bees, including down-regulation of buffy and mrjps and up-regulation of hbg3 and ilp1 may...Continue Reading

References

Apr 27, 2002·Science·Y Ben-ShaharG E Robinson
Oct 11, 2003·Science·Charles W WhitfieldGene E Robinson
Mar 26, 2004·Ecotoxicology and Environmental Safety·Axel DecourtyeMinh-Hà Pham-Delègue
Oct 5, 2010·Journal of Insect Physiology·Sergio Vicente AzevedoKlaus Hartfelder
Jan 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sydney A CameronTerry L Griswold
Mar 15, 2012·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Kimberly A Maguschak, Kerry J Ressler
Mar 31, 2012·Science·Mickaël HenryAxel Decourtye
May 2, 2012·Proceedings of the National Academy of Sciences of the United States of America·Virginia A RauhBradley S Peterson
Oct 23, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gennaro Di PriscoFrancesco Pennacchio
Apr 11, 2014·PloS One·Francisco Sanchez-Bayo, Koichi Goka
Oct 16, 2015·Scientific Reports·Geoffrey R WilliamsLaurent Gauthier
Mar 19, 2016·Environmental Science & Technology·Verena ChristenKarl Fent
Jun 9, 2016·Environmental Science & Technology·Léa TisonRandolf Menzel
Jul 29, 2016·Proceedings. Biological Sciences·Lars StraubGeoffrey R Williams
Jan 13, 2017·Environmental Science & Technology·Ciaran EllisDave Goulson
Apr 8, 2017·Toxicology and Applied Pharmacology·Verena ChristenKarl Fent
Jan 11, 2019·Insects·Nancy OstiguyWalter S Sheppard
Sep 14, 2019·Science·Margaret L EngChristy A Morrissey

❮ Previous
Next ❯

Citations

Aug 28, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aleksandra LeskaAnna Górczyńska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.