Insensitivity of auditory mismatch negativity to classical fear conditioning and extinction in healthy humans

Neuroreport
Taichi KurayamaEiji Shimizu

Abstract

The relationship between auditory mismatch negativity (MMN) and the neural cognitive processes of fear has been suggested in both healthy participants and patients with fear-related mental disorders such as post-traumatic stress disorder and panic disorder. The present study sought to confirm whether the MMN is affected by classical fear conditioning in healthy participants. MMN amplitude, N1 amplitude, and skin conductance level (SCL) in 20 healthy volunteers during a fear-conditioning paradigm consisting of three phases (habituation, fear acquisition, and fear extinction) were recorded. Red and blue light signals were presented as the conditioned stimuli CS+ (threat cue) and CS- (safety cue), respectively. In addition, an aversive electrical stimulus was delivered as the unconditioned stimulus with CS+ in the fear-acquisition phase. No MMN amplitude changes were observed between the CS types during the three phases. In the acquisition phase, the mean SCL during CS+ was significantly higher than that during CS-. The MMN amplitude and deviant N1 amplitude in the extinction phase were significantly lower than those in the other phases regardless of the CS type. Despite the clear alteration of SCL between CS types in the acquisit...Continue Reading

References

Jul 1, 1978·Acta Psychologica·R NäätänenS Mäntysalo
Dec 24, 1997·Psychophysiology·M Sallinen, H Lyytinen
Feb 7, 2001·Current Opinion in Neurobiology·C Büchel, R J Dolan
Apr 11, 2000·Neuroreport·L J OttenT W Picton
May 5, 2001·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H NittonoT Hori
Feb 26, 2003·European Journal of Pharmacology·Matthew J SandersMichael S Fanselow
Jan 7, 2004·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Risto NäätänenRika Takegata
May 12, 2005·Behaviour Research and Therapy·Shmuel LissekDaniel S Pine
Jan 5, 2007·Behavioral Neuroscience·Dominic T ChengFred J Helmstetter
Aug 19, 2007·Journal of Abnormal Psychology·Tanja MichaelFrank H Wilhelm
Nov 10, 2007·Psychosomatic Medicine·Jens BlechertFrank H Wilhelm
Feb 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Marta I GarridoKarl J Friston
Oct 3, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Connie C DuncanCyma Van Petten
Nov 10, 2009·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Annett Schirmer, Nicolas Escoffier
Jan 19, 2012·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Taichi KurayamaEiji Shimizu
Jan 1, 2011·Biology of Mood & Anxiety Disorders·Arash JavanbakhtNash N Boutros

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