Insensitivity versus poor response to tumour necrosis factor inhibitors in rheumatoid arthritis: a retrospective cohort study

Arthritis Research & Therapy
Sae OchiYoshiya Tanaka

Abstract

With advancement in the treatment options of rheumatoid arthritis (RA), optimising the outcomes of difficult-to-treat patients has become increasingly important in clinical practice. In particular, insensitivity to first-line biologic disease-modifying anti-rheumatic drugs (bDMARD) is becoming a significant problem because it may decrease the treatment adherence of patients. This study aimed to compare RA patients with an insensitivity and those with a poor response to initial treatment with tumour necrosis factor inhibitors (TNFis), which are the most frequently used bDMARDs. This is a retrospective cohort study using clinical data from the FIRST registry. bDMARD-naïve RA patients treated with tumour necrosis factor inhibitors (TNFis) from August 2003 to May 2019 were included and categorised into three groups: TNFi insensitivity, poor response to TNFis and controls. TNFi insensitivity was defined as follows: (1) discontinuation of TNFi treatment within 22 weeks due to lack of any response, or (2) an increase in the disease activity score in 28 joints-C-reactive protein (DAS28-CRP) of > 0.6 at week 22 compared with week 0. Among the remaining patients, those with a DAS28-CRP > 2.6 at week 22 were categorised in the poor respon...Continue Reading

References

Nov 30, 2000·The New England Journal of Medicine·P E LipskyUNKNOWN Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group
Mar 2, 2006·Arthritis and Rheumatism·Josef S SmolenUNKNOWN Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) S
Mar 30, 2007·Annals of the Rheumatic Diseases·Mahboob U RahmanRene Westhovens
Jan 13, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ellen C Ebert
May 20, 2009·Annals of the Rheumatic Diseases·Lilian H D van TuylAlexandre E Voskuyl
Mar 6, 2012·Current Opinion in Rheumatology·Yoshiya Tanaka
Jun 26, 2012·Arthritis Care & Research·Elisa GremeseUNKNOWN Gruppo Italiano di Studio sulle Early Arthritis (GISEA)
Dec 21, 2012·Annals of the Rheumatic Diseases·Yoshiya Tanaka
Feb 20, 2013·Nature Reviews. Rheumatology·Ernest H ChoySimon A Jones
Mar 5, 2016·The Korean Journal of Internal Medicine·Yoshiya Tanaka
Mar 29, 2018·Annals of the Rheumatic Diseases·Maya H Buch
Sep 9, 2018·Annals of the Rheumatic Diseases·Nadia M T RoodenrijsUNKNOWN whole EULAR Task Force on development of EULAR recommendations for the comprehensive management of difficult-to-treat rheuma

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