PMID: 15359588Sep 14, 2004Paper

Insertion and partition of sodium taurocholate into egg phosphatidylcholine vesicles

Pharmaceutical Research
Karine AndrieuxCécile Grabielle-Madelmont

Abstract

To get a continuous description of the insertion and partition processes of sodium taurocholate (TC) into the lipid bilayers of vesicles that can serve as a model for understanding the mechanism of destabilization by the bile salts of liposomes used as drug carriers for oral administration. The progressive solubilization of egg phosphatidylcholine vesicles during TC addition at controlled rates was followed by continuous turbidity (OD) and resonance energy transfer (RET) between two fluorescent probes. The influence of the lipid and TC concentrations as well as the rate of TC addition on the processes were examined. Continuous turbidity recordings allowed following of the size and composition evolutions of the mixed TC/lipid aggregates formed at different steps of the vesicle-micelle transition. The solubilization mechanism is governed by complex kinetics that depend on the surfactant concentration and its addition rate. A two-step process characterizes the evolution of the vesicular state: interaction of TC molecules with the external monolayer of the vesicles first occurs. The homogeneous distribution of TC within the lipid matrix after its insertion is a very slow process. A micellar structural reorganization is observed whe...Continue Reading

Citations

Jul 27, 2010·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Giorgio OttavianiBernard Faller
Oct 7, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Karine AndrieuxCécile Grabielle-Madelmont
Jul 10, 2007·International Journal of Pharmaceutics·M LalanneP Couvreur
Aug 22, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·José Mario BarichelloHiroshi Kiwada
Sep 22, 2010·Journal of Liposome Research·Laura G HermidaRamon Barnadas-Rodríguez
Sep 11, 2007·Drug Metabolism and Pharmacokinetics·Kiyohiko SuganoTakashi Mano
Jul 10, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jariya KowapraditPraneet Opanasopit
Feb 18, 2011·Chemistry : a European Journal·Craig P WilsonSimon J Webb
Apr 2, 2019·Chemical & Pharmaceutical Bulletin·Shin-Ya MoritaTomohiro Terada
Nov 4, 2009·Pharmaceutical Development and Technology·Amornrat ViriyarojPraneet Opanasopit
Jan 24, 2014·Journal of Agricultural and Food Chemistry·Sophie GallierRafael Jiménez-Flores
Oct 30, 2007·Chemistry and Physics of Lipids·Marité CárdenasThomas Arnebrant
Feb 26, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Federico MazurBrigitte Städler
May 27, 2009·International Journal of Pharmaceutics·Muriel LalanneKarine Andrieux

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