PMID: 15388343DOI: 10.1016/j.febslet.2004.08.045Sep 25, 2004Paper
Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides
FEBS Letters
Hedvig Tordai, L Patthy
Abstract
Analysis of the exon-intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.
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