Insertion of spliceosomal introns in proto-splice sites: the case of secretory signal peptides

FEBS Letters
Hedvig Tordai, L Patthy

Abstract

Analysis of the exon-intron structures of 2208 human genes has revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites. It is suggested that amino acid sequences surrounding signal peptide cleavage sites are significantly enriched in phase 1 proto-splice sites and this has favored insertion of spliceosomal introns in these sites.

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Citations

Jun 1, 2006·Journal of Molecular Evolution·A Ruvinsky, W Ward
Aug 1, 2008·Molecular Biology and Evolution·Angela R OmilianMichael Lynch
Nov 11, 2006·Annual Review of Genetics·Francisco Rodríguez-TrellesFrancisco J Ayala
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May 30, 2020·PloS One·Eugene F BaulinTatiana V Astakhova

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