Insertion/deletion polymorphism of angiotensin converting enzyme gene in Kawasaki disease.

Journal of Korean Medical Science
Yoon Hee ShimYoung Mi Hong

Abstract

Polymorphism of angiotensin converting enzyme (ACE) gene is reported to be associated with ischemic heart disease, hypertrophic cardiomyopathy, and idiopathic dilated cardiomyopathy. In this study, we investigated the relationship between Kawasaki disease and insertion/deletion polymorphism of ACE gene. Fifty five Kawasaki disease patients and 43 healthy children were enrolled. ACE genotype was evaluated from each of the subjects' DNA fragments through polymerase chain reaction (PCR). Frequencies of ACE genotypes (DD, ID, II) were 12.7%, 60.0%, 27.3% in Kawasaki group, and 41.9%, 30.2%, 27.9% in control group respectively, indicating low rate of DD and high rate of ID genotype among Kawasaki patients (p<0.01). Comparing allelic (I, D) frequencies, I allele was more prevalent in Kawasaki group than in control group (57.3% vs. 43.0%, p<0.05). In Kawasaki group, both genotype and allelic frequencies were not statistically different between those with coronary dilatations and those without. ACE gene I/D polymorphism is thought to be associated with Kawasaki disease but not with the development of coronary dilatations.

References

Mar 12, 1976·Science·P R CaldwellR L Soffer
Nov 1, 1992·European Journal of Pediatrics·K HagiwaraT Yoshida
Sep 6, 1986·Lancet·S T Shulman, A H Rowley
Feb 1, 1997·Clinical and Experimental Immunology·N YamashitaT Sakane
Apr 28, 1999·Pediatric Clinics of North America·A H Rowley, S T Shulman
Jan 2, 2004·Pediatrics·Christian RochollCarrie L Byington
May 28, 2004·Pediatric Cardiology·S-F WuF-J Tsai
May 29, 2004·Stroke; a Journal of Cerebral Circulation·Agnieszka SlowikAndrzej Szczudlik
Sep 16, 2004·Current Opinion in Pediatrics·Jane W Newburger, David R Fulton
Jan 19, 2005·The Journal of Infectious Diseases·Frank EsperJeffrey S Kahn
Feb 8, 2005·Atherosclerosis·W Douglas ScheerJack P Strong
Mar 22, 2005·Archives of Medical Research·Chung-Tei ChouChang-Youh Tsai

❮ Previous
Next ❯

Citations

Oct 23, 2009·Rheumatology International·Mohamed-Mofeed Fawaz MorsyMohamed Ali Ismail
Mar 16, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Paul A Brogan
Jul 17, 2008·Journal of Clinical Immunology·Won Kyoung JhangSoo-Jong Hong
Apr 5, 2011·Journal of Community Health·Benrithung MurryK N Saraswathy
Apr 23, 2013·The Journal of Infection·Nicola PrincipiSusanna Esposito
Sep 6, 2011·Acta Pharmacologica Sinica·Ho-chang Kuo, Wei-chiao Chang
Mar 28, 2013·Computational and Mathematical Methods in Medicine·Yu-wen LvHai-tao Lv
Mar 14, 2013·PloS One·Chisato ShimizuJane C Burns
Mar 23, 2010·Cancer Genetics and Cytogenetics·Muradiye NacakA Sükrü Aynacioğlu
May 19, 2010·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Sinda MahjoubSaida Ben Arab
Jul 27, 2007·Basic & Clinical Pharmacology & Toxicology·Muradiye NacakRukiye Nalan Tiftik
Jan 23, 2009·Journal of Human Genetics·Akira Hata, Yoshihiro Onouchi
Feb 5, 2009·Pediatric Research·Yoshihiro Onouchi
May 23, 2017·Frontiers in Cardiovascular Medicine·Sara Abou SherifIsmail Dogu Kilic
Jan 27, 2012·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Young Ho LeeGwan Gyu Song
Mar 23, 2020·Clinical Reviews in Allergy & Immunology·Rajni KumrahSurjit Singh
Sep 25, 2020·FEBS Open Bio·Antonio FacchianoAngelo Facchiano

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.