Inside prostate cancer news from the 2021 ASCO Genitourinary Cancers Symposium.

Expert Review of Anticancer Therapy
Roberto IacovelliGiampaolo Tortora

Abstract

Prostate cancer (PC) is a heterogeneous disease that requires a personalized treatment approach for proper patient management. We analyzed a selected overview of the most important news recently presented at the 2021 ASCO genitourinary cancer symposium. In particular, we focused on the identification of predictive biomarkers as potential targets for therapy. Molecular signatures of increased T cell activity, proliferation, and hormone dependence were associated with greater probability of response to apalutamide in non-metastatic CRPC. Pathogenic variants of DDR genes mutations detected with circulating tumor DNA (ctDNA) analysis, which had a high concordance with tumor tissue analysis, might represent a useful way for selecting mutated patients for poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors therapy. Loss of PTEN could be a target for ipatasertib (a pan-AKT inhibitor) associated with abiraterone in mCRPC patients. The 2021 ASCO Genitourinary Cancers Symposium significantly contributed to the complex research goal of intimately understanding PC carcinogenesis with the ultimate aim of improving patient outcomes.

References

Jun 26, 2009·Journal of Immunological Methods·Philippe O GannonFred Saad
May 23, 2015·Cell·Dan RobinsonArul M Chinnaiyan
Jul 20, 2016·The New England Journal of Medicine·Colin C PritchardPeter S Nelson
Feb 15, 2019·The New England Journal of Medicine·Karim FizaziUNKNOWN ARAMIS Investigators
Jan 29, 2020·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E J SmallM R Smith
Apr 29, 2020·The New England Journal of Medicine·Johann de BonoMaha Hussain
May 30, 2020·The New England Journal of Medicine·Cora N SternbergUNKNOWN PROSPER Investigators

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