Insight in Adhesion Protein Sialylation and Microgravity Dependent Cell Adhesion-An Omics Network Approach

International Journal of Molecular Sciences
Thomas J BauerDaniela Grimm

Abstract

The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modification (PTM) regarding changes during exposure to microgravity were investigated. As the sialylation of adhesion proteins is influencing cell adhesion on Earth in vitro and in vivo, we analyzed the sialylation of cell adhesion molecules detected by omics studies on cells, which change their adhesion behavior when exposed to microgravity. Using a knowledge graph created from experimental omics data and semantic searches across several reference databases, we studied the sialylation of adhesion proteins glycosylated at their extracellular domains with regards to its sensitivity to microgravity. This way, experimental omics data networked with the current knowledge about the binding of sialic acids to cell adhesion proteins, its regulation, and interactions in between those proteins provided insights into the mechanisms behind our experimental findings, suggesting that balancing the sialylation against the de-sialylatio...Continue Reading

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Citations

Mar 27, 2020·International Journal of Molecular Sciences·Johann Bauer
Apr 30, 2020·International Journal of Molecular Sciences·Xiao LinAirong Qian
Oct 9, 2020·International Journal of Molecular Sciences·Mohamed Zakaria NassefMarcus Krüger

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Software Mentioned

UniProt
Pathway Studio plus
SPARQL
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Knowledge Explorer ( KE )
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