Abstract
The mechanisms of interaction between inorganic matter and biomolecules, as well as properties of resulting hybrids, are receiving growing interest due to the rapidly developing field of bionanotechnology. The majority of potential applications for metal-biohybrid structures require stability of these systems under vacuum conditions, where their chemistry is elusive, and may differ dramatically from the interaction between biomolecules and metal ions in vivo. Here we report for the first time a photoemission and X-ray absorption study of the formation of a hybrid metal-protein system, tracing step-by-step the chemical interactions between the protein and metals (Cu and Fe) in vacuo. Our experiments reveal stabilization of the enol form of peptide bonds as the result of protein-metal interactions for both metals. The resulting complex with copper appears to be rather stable. In contrast, the system with iron decomposes to form inorganic species like oxide, carbide, nitride, and cyanide.
References
Jan 15, 1989·Physical Review. B, Condensed Matter·M GrioniR C Karnatak
Dec 15, 1995·Physical Review. B, Condensed Matter·T Schedel-NiedrigR Schlögl
Nov 13, 2004·Angewandte Chemie·Eugenii Katz, Itamar Willner
Sep 10, 2005·Microbiology·Katrin PollmannSonja Selenska-Pobell
Mar 3, 2006·The Journal of Physical Chemistry. B·Katsumasa KamiyaAtsushi Oshiyama
May 16, 2006·Advances in Colloid and Interface Science·Yuan-Pang SunH Paul Wang
Aug 10, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Imre Sóvágó, Katalin Osz
Nov 14, 2007·The Journal of Physical Chemistry. B·Andreas KadeSerguei L Molodtsov
Sep 2, 2008·The Journal of Biological Chemistry·F Peter Guengerich
Apr 29, 2009·Physics in Medicine and Biology·Song GeBradford G Orr
Apr 13, 2010·Inorganic Chemistry·Ryan L Shook, A S Borovik
Jul 9, 2010·The Journal of Physical Chemistry. B·Kurt KummerSerguei L Molodtsov
Feb 23, 2011·The Journal of Physical Chemistry. B·Kurt KummerSerguei L Molodtsov
Jul 29, 2011·Inorganic Chemistry·Gary K-Y NgA S Borovik
Aug 3, 2011·The Journal of Chemical Physics·Phillip S JohnsonF J Himpsel
Apr 5, 2012·Angewandte Chemie·Robert C DunbarJos Oomens
Aug 28, 2012·Nature Materials·Bozhi TianCharles M Lieber
Apr 2, 2013·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·E Mateo-Marti, C M Pradier
Jun 22, 2013·Journal of the American Chemical Society·Xuan-He LiuLi-Jun Wan
Aug 16, 2013·Chemistry, an Asian Journal·Xiaojie Duan, Charles M Lieber
Citations
Nov 18, 2015·Inorganic Chemistry·Lada V YashinaAndrei V Shevelkov
May 26, 2016·Scientific Reports·Adrienne KishFrançois Guyot
Mar 3, 2017·The Journal of Physical Chemistry. B·Ivan L VolkovAlexei I Kononov
Sep 18, 2015·Chemical Communications : Chem Comm·Hao LuTobias Weidner
Aug 29, 2018·Chemical Communications : Chem Comm·Bart StelMagalí Lingenfelder
Apr 10, 2020·Advanced Materials·Wen QinLi-Na Niu
Apr 6, 2019·ChemSusChem·Sanghoon KimBruno Boury
Feb 13, 2021·Journal of the American Society for Mass Spectrometry·Simon DörnerSadia Bari
Nov 14, 2020·Carbohydrate Polymers·Mikhail V TsurkanHermann Ehrlich
Jun 3, 2021·Microorganisms·Laurens MaertensJean-Yves Matroule