Insight into norcantharidin, a small-molecule synthetic compound with potential multi-target anticancer activities

Chinese Medicine
Mu-Su PanYue-Zu Fan

Abstract

Norcantharidin (NCTD) is a demethylated derivative of cantharidin, which is an anticancer active ingredient of traditional Chinese medicine, and is currently used clinically as a routine anti-cancer drug in China. Clarifying the anticancer effect and molecular mechanism of NCTD is critical for its clinical application. Here, we summarized the physiological, chemical, pharmacokinetic characteristics and clinical applications of NCTD. Besides, we mainly focus on its potential multi-target anticancer activities and underlying mechanisms, and discuss the problems existing in clinical application and scientific research of NCTD, so as to provide a potential anticancer therapeutic agent for human malignant tumors.

References

Jun 5, 1991·Journal of the National Cancer Institute·A AlbiniW G Stetler-Stevenson
Sep 1, 1989·Journal of Ethnopharmacology·G S Wang
Jun 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·X H LiuJ L Misset
Jan 1, 1996·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·P MackL Y Cheng
Sep 17, 1999·The American Journal of Pathology·A J ManiotisM J Hendrix
Sep 28, 2000·Biochemical and Biophysical Research Communications·C Y HongM Hsiao
Apr 26, 2001·The American Journal of Chinese Medicine·L T WuW Tsauer
Mar 21, 2002·Nature Reviews. Cancer·Michael M GottesmanSusan E Bates
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Yan-Nian ChenShih-Lan Hsu
Mar 31, 2004·Bioorganic & Medicinal Chemistry Letters·Matthew E HartAdam McCluskey
Aug 17, 2004·Journal of Korean Medical Science·Wei-Wei AnTakashi Ikejima
Oct 7, 2004·Genes & Development·Anders H Lund, Maarten van Lohuizen
Apr 16, 2005·World Journal of Gastroenterology : WJG·Yue-Zu FanCun-Qiu Chen
Apr 20, 2005·Cancer Letters·Julien MazieresDavid M Jablons
May 20, 2005·Nature·Tilman OltersdorfSaul H Rosenberg
Sep 24, 2005·Cell·Nagi G Ayad
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Marc G Achen, Steven A Stacker
May 9, 2006·Cancer Metastasis Reviews·Elena I Deryugina, James P Quigley
May 10, 2006·Investigational New Drugs·Nico JanssensTim Perera
Apr 20, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hui-Fen LiaoCheng-Deng Kuo
Jul 17, 2007·Cell·Marc Mumby
Sep 26, 2007·Anti-cancer Drugs·Huayu YangJingrong Cui
May 3, 2008·Cancer Research·Christin TseSteven W Elmore
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph BergmannTheresa L Whiteside
Jan 7, 2009·International Journal of Cancer. Journal International Du Cancer·David C DornMalcolm A S Moore
Aug 25, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Qin WangQiang Zhang
Nov 17, 2009·Cancer Investigation·Nektaria MakriliaKostas Syrigos
Dec 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David JackmanVincent A Miller
Dec 31, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Pei-Yu YangYang-Chang Wu
Mar 25, 2010·Molecular Biology Reports·Cheng ChangWenhui Tao

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
xenograft

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.