PMID: 22586728May 16, 2012Paper

Insight into pressure drop dependent efficiencies of dry powder inhalers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Srinivas Ravindra Babu BeharaDavid A V Morton

Abstract

The purpose of this study was to assess the effectiveness of three commercial capsule-based dry powder passive inhalers [Rotahaler® (RH), Monodose Inhaler® (MI) and Handihaler® (HH)] in de-agglomerating salbutamol sulphate (SS) and micronized lactose (LH300) powders and their sensitivity to air flow rate changes and air flow resistance. Aerosolisation was assessed in real-time using a laser diffraction method: this approach was possible as only single-component formulations were tested. Volume percent of the aerosolised particles with diameter less than 5.4 μm at air flow rates from 30 to 180 l min−1 was obtained with the RH, MI and HH and provided a parameter, relative de-agglomeration (RD), as a measure of de-agglomeration. The pressure drops across the device at various flow rates were obtained from a differential pressure meter. The relationship between RD of SS and LH300 and air flow rate appeared substantially different between the devices. It was surprisingly found that in some cases RD dropped at the highest air flows: this indicates a device specific maxima in RD occurs, and this may in part be attributed to changes in capsule motion. It is proposed that this relationship between RD and pressure drop provides a patient...Continue Reading

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Oct 4, 2011·International Journal of Pharmaceutics·Srinivas Ravindra Babu BeharaPeter Stewart

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Citations

Jun 15, 2012·Pharmaceutical Research·Shyamal C DasPeter J Stewart
Dec 7, 2013·Journal of Pharmaceutical Sciences·Srinivas R B BeharaMichael Hindle
Jun 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anthony J Hickey
May 24, 2012·Journal of Pharmaceutical Sciences·Nashwa El-GendyCory Berkland
Dec 17, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Susanne ZiffelsAnthony J Hickey
Jan 1, 2014·International Journal of Pharmaceutics·Warangkana PornputtapitakCory Berkland
Nov 11, 2017·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Conor A RuzyckiWarren H Finlay

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