Insight into the fundamental trade-offs of diffusion MRI from polarization-sensitive optical coherence tomography in ex vivo human brain.

NeuroImage
Robert JonesAnastasia Yendiki

Abstract

In the first study comparing high angular resolution diffusion MRI (dMRI) in the human brain to axonal orientation measurements from polarization-sensitive optical coherence tomography (PSOCT), we compare the accuracy of orientation estimates from various dMRI sampling schemes and reconstruction methods. We find that, if the reconstruction approach is chosen carefully, single-shell dMRI data can yield the same accuracy as multi-shell data, and only moderately lower accuracy than a full Cartesian-grid sampling scheme. Our results suggest that current dMRI reconstruction approaches do not benefit substantially from ultra-high b-values or from very large numbers of diffusion-encoding directions. We also show that accuracy remains stable across dMRI voxel sizes of 1 ​mm or smaller but degrades at 2 ​mm, particularly in areas of complex white-matter architecture. We also show that, as the spatial resolution is reduced, axonal configurations in a dMRI voxel can no longer be modeled as a small set of distinct axon populations, violating an assumption that is sometimes made by dMRI reconstruction techniques. Our findings have implications for in vivo studies and illustrate the value of PSOCT as a source of ground-truth measurements of ...Continue Reading

References

Jan 1, 1994·Biophysical Journal·P J BasserD LeBihan
Oct 12, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·P J BasserA Aldroubi
Mar 29, 2001·Journal of Magnetic Resonance Imaging : JMRI·D Le BihanH Chabriat
Apr 12, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J-D TournierA Connelly
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Nov 25, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·David S Tuch
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Muriel PerrinDenis Lebihan
Oct 26, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Van J WedeenRobert M Weisskoff
Feb 13, 2007·NeuroImage·Helen E D'ArceuilAlex J de Crespigny
Apr 17, 2007·NeuroImage·Helen D'Arceuil, Alex de Crespigny
Sep 1, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maxime DescoteauxRachid Deriche
Aug 5, 2008·Journal of Neuroscience Methods·Haruo NakajiHiroshi Iseki
Nov 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cyril PouponJean-François Mangin
Mar 26, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Erick Jorge Canales-RodríguezYasser Iturria-Medina
Apr 7, 2009·Bioinformatics·Stephan PreibischPavel Tomancak
Mar 23, 2010·IEEE Transactions on Medical Imaging·Fang-Cheng YehWen-Yih Isaac Tseng
Jun 11, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Iman AganjNoam Harel
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Jul 15, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Julia F LehmanSuzanne N Haber
Feb 16, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Saad JbabdiTimothy E J Behrens
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Mar 19, 2013·Biomedical Optics Express·Chuanmao Fan, Gang Yao
Apr 30, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Emmanuel CaruyerRachid Deriche
May 21, 2013·NeuroImage·David C Van EssenUNKNOWN WU-Minn HCP Consortium
Jun 26, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Cornelius EichnerRobin M Heidemann
Oct 18, 2013·IEEE Transactions on Medical Imaging·Alessandro DaducciJean-Philippe Thiran
Jul 25, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sarah R Heilbronner, Suzanne N Haber
Feb 11, 2015·NeuroImage·Ahmad Raza KhanChristopher D Kroenke

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Noel M Naughton, John G Georgiadis
Frontiers in Neuroinformatics
Ipek OguzMartin Styner
© 2021 Meta ULC. All rights reserved