Insight into the mechanism of action of dimethyl fumarate in multiple sclerosis

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Sudhir Kumar YadavSuhayl Dhib-Jalbut

Abstract

Dimethyl fumarate (DMF) is an oral, disease-modifying agent for the treatment of relapsing-remitting multiple sclerosis (RRMS). However, details regarding its mode of action are still emerging. It is believed that the mode of action of DMF involves both nuclear factor erythroid-derived 2-related factor (Nrf2)-dependent and independent pathways, which lead to an anti-inflammatory immune response due to type II myeloid cell and Th2 cell differentiation and neuroprotection. In this review, we will focus on the molecular and signaling effects of DMF that lead to changes in peripheral immune cell composition and function, alteration in CNS cell-specific functions, and effect on the blood-brain barrier.

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Oct 24, 2019·International Journal of Molecular Sciences·Sara PetrilloFiorella Piemonte
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Methods Mentioned

BETA
flow cytometry
biopsy

Software Mentioned

DEFINE
CONFIRM

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