Feb 18, 2016

Insight into the Molecular Imaging of Alzheimer's Disease

International Journal of Biomedical Imaging
Abishek Arora, Neeta Bhagat

Abstract

Alzheimer's disease is a complex neurodegenerative disease affecting millions of individuals worldwide. Earlier it was diagnosed only via clinical assessments and confirmed by postmortem brain histopathology. The development of validated biomarkers for Alzheimer's disease has given impetus to improve diagnostics and accelerate the development of new therapies. Functional imaging like positron emission tomography (PET), single photon emission computed tomography (SPECT), functional magnetic resonance imaging (fMRI), and proton magnetic resonance spectroscopy provides a means of detecting and characterising the regional changes in brain blood flow, metabolism, and receptor binding sites that are associated with Alzheimer's disease. Multimodal neuroimaging techniques have indicated changes in brain structure and metabolic activity, and an array of neurochemical variations that are associated with neurodegenerative diseases. Radiotracer-based PET and SPECT potentially provide sensitive, accurate methods for the early detection of disease. This paper presents a review of neuroimaging modalities like PET, SPECT, and selected imaging biomarkers/tracers used for the early diagnosis of AD. Neuroimaging with such biomarkers and tracers c...Continue Reading

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Citations

Mentioned in this Paper

Biological Markers
Metabolic Process, Cellular
Establishment and Maintenance of Localization
Molecular Imaging
Pathogenic Aspects
AZD 2184
Blood - Brain Barrier Anatomy
Pyridines
Brain Diseases
Diagnostic Radiology Modality

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