Insight into the solubility and dissolution behavior of piroxicam anhydrate and monohydrate forms

International Journal of Pharmaceutics
Urve PaaverKarin Kogermann

Abstract

The aim of the present study was two-fold: (1) to investigate the effect of pH and presence of surfactant sodium lauryl sulphate (SLS) on the solubility and dissolution rate of two solid-state forms of piroxicam (PRX), anhydrate (PRXAH) and monohydrate (PRXMH), and (2) to quantitatively assess the solid-phase transformation of PRXAH to PRXMH in slurry with a special interest to the impact on the solubility and dissolution behavior of the drug. X-ray powder diffractometry (XRPD), Raman spectroscopy and scanning electron microscopy (SEM) were used for characterization of the solid-state forms. Phase transformation was monitored in slurry by means of in-line Raman spectroscopy, and the partial least squares (PLS) regression model was used for predicting the amount of PRXMH. The results showed that the solubility and dissolution rate of PRXAH were higher compared to PRXMH at different pHs. The pH and presence of SLS together affected the solubility and dissolution rate of different PRX forms. The lowest solubility values and dissolution rates for PRX forms were observed in distilled water (pH 5.6) at 37 °C. The changes in the dissolution rate could be explained by the hydrate formation during solubility testing. The rate of hydrate...Continue Reading

References

May 1, 1986·Journal of Pharmaceutical Sciences·J H de SmidtD J Crommelin
Mar 28, 2003·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Rona BanerjeeMunna Sarkar
May 20, 2003·International Journal of Pharmaceutics·R Barreiro-IglesiasA Concheiro
Feb 14, 2004·Advanced Drug Delivery Reviews·Geoff G Z ZhangYihong Qiu
Mar 12, 2005·Journal of Pharmaceutical Sciences·Håkan WikströmLynne S Taylor
May 24, 2005·International Journal of Pharmaceutics·Hye-Sun GwakHoo-Kyun Choi
May 24, 2005·Biophysical Chemistry·Hirak Chakraborty, Munna Sarkar
Jun 27, 2006·International Journal of Pharmaceutics·Sung-Hyun Park, Hoo-Kyun Choi
Aug 8, 2006·Journal of Pharmaceutical Sciences·Jaakko AaltonenJukka Rantanen
Aug 19, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lennart LindforsUlf Olsson
Aug 25, 2007·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andrea HeinzClare J Strachan
Mar 21, 2008·Journal of Pharmaceutical Sciences·Karin KogermannJukka Rantanen
May 7, 2008·AAPS PharmSciTech·Ashok R Patel, Vishal Y Joshi
Apr 18, 2009·Journal of Pharmaceutical Sciences·Joachim BrouwersPatrick Augustijns
May 1, 2009·Journal of Colloid and Interface Science·Subhashis ChakrabortySanjay Singh
Feb 24, 2011·Journal of Pharmaceutical Sciences·Vishal KoradiaJukka Rantanen
Apr 30, 2011·International Journal of Pharmaceutics·Shobha N BhattacharAktham Aburub

❮ Previous
Next ❯

Citations

Jun 13, 2015·Drug Development and Industrial Pharmacy·Anna PenkinaJyrki Heinämäki
Aug 2, 2013·Journal of Pharmaceutical Sciences·Dhara RaijadaNiklas Sandler
Oct 23, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Andres LustKarin Kogermann
Apr 6, 2016·Results in Pharma Sciences·Maria L GuzmanErika S Stippler
Sep 12, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Jochem AlsenzGiorgio Cirelli
Sep 3, 2013·International Journal of Pharmaceutics·Andres LustKarin Kogermann
Jan 1, 2015·International Journal of Pharmaceutics·Urve PaaverKarin Kogermann
Feb 15, 2017·Molecular Pharmaceutics·Mirja PaloNiklas Sandler
Mar 21, 2018·Pharmaceutical Development and Technology·Shahram EmamiMohammadreza Siahi-Shadbad
Apr 30, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jessica OtarolaPatricia G Molina
Feb 14, 2020·Current Pharmaceutical Design·Beiqian TianHongxun Hao

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Andres LustKarin Kogermann
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Karin KogermannKaisa Naelapää
© 2021 Meta ULC. All rights reserved