Insight into unique somitogenesis of yak (Bos grunniens) with one additional thoracic vertebra

BMC Genomics
Yu WangYongli Wen

Abstract

The yak is a species of livestock which is crucial for local communities of the Qinghai-Tibet Plateau and adjacent regions and naturally owns one more thoracic vertebra than cattle. Recently, a sub-population of yak termed as the Jinchuan yak has been identified with over half its members own a thoracolumbar vertebral formula of T15L5 instead of the natural T14L5 arrangement. The novel T15L5 positioning is a preferred genetic trait leading to enhanced meat and milk production. Selective breeding of this trait would have great agricultural value and exploration of the molecular mechanisms underlying this trait would both accelerate this process and provide us insight into the development and regulation of somitogenesis. Here we investigated the genetic background of the Jinchuan yak through resequencing fifteen individuals, comprising five T15L5 individuals and ten T14L5 individuals with an average sequencing depth of > 10X, whose thoracolumbar vertebral formulae were confirmed by anatomical observation. Principal component analysis, linkage disequilibrium analysis, phylogenetic analysis, and selective sweep analysis were carried out to explore Jinchuan yak's genetic background. Three hundred and thirty candidate markers were id...Continue Reading

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Datasets Mentioned

BETA
PRJNA435474

Methods Mentioned

BETA
PCA
transgenic
ubiquitination

Software Mentioned

MAS
MEM
GenotypeGVCF
PLINK
ggtree
smartpca
LASTZ
vcftools
PHYLIP
CIRCOS

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