Insights From Modeling Preventive Supplemental Immunization Activities as a Strategy to Eliminate Wild Poliovirus Transmission in Pakistan and Afghanistan.

Risk Analysis : an Official Publication of the Society for Risk Analysis
Dominika A Kalkowska, Kimberly M Thompson

Abstract

Many countries use supplemental immunization activities (SIAs) with oral poliovirus vaccine (OPV) to keep their population immunity to transmission high using preventive, planned SIAs (pSIAs) and outbreaks response SIAs (oSIAs). Prior studies suggested that investment in pSIAs saved substantial health and financial costs due to avoided outbreaks. However, questions remain about the benefits of SIAs, particularly with the recent introduction of inactivated poliovirus vaccine (IPV) into routine immunization in all OPV-using countries. The mounting costs of polio eradication activities and the need to respond to oSIAs threatens the use of limited financial resources for pSIAs, including in the remaining countries with endemic transmission of serotype 1 wild poliovirus (WPV1) (i.e., Pakistan and Afghanistan). A recent updated global poliovirus transmission model suggested that the Global Polio Eradication Initiative (GPEI) is not on track to stop transmission of WPV1 in Pakistan and Afghanistan. We use the updated global model to explore the role of pSIAs to achieve WPV1 eradication. We find that unless Pakistan and Afghanistan manage to increase the quality of bivalent OPV (bOPV) pSIAs, which we model as intensity (i.e., sufficien...Continue Reading

References

Apr 24, 2007·Lancet·Kimberly M Thompson, Radboud J Duintjer Tebbens
Sep 19, 2012·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M ThompsonStephen L Cochi
Oct 16, 2014·The Journal of Infectious Diseases·Kimberly M Thompson, Radboud J Duintjer Tebbens
Oct 16, 2014·The Journal of Infectious Diseases·Radboud J Duintjer Tebbens, Kimberly M Thompson
Apr 25, 2017·Expert Review of Vaccines·Radboud J Duintjer Tebbens, Kimberly M Thompson
Aug 26, 2017·The Journal of Infectious Diseases·Lee M HamptonManish Patel
Jan 10, 2018·Risk Analysis : an Official Publication of the Society for Risk Analysis·Radboud J Duintjer TebbensKimberly M Thompson
Jul 31, 2018·Expert Review of Vaccines·Radboud J Duintjer Tebbens, Kimberly M Thompson
Sep 22, 2018·Risk Analysis : an Official Publication of the Society for Risk Analysis·Radboud J Duintjer Tebbens, Kimberly M Thompson
Jun 30, 2019·Expert Review of Vaccines·Kimberly M Thompson, Dominika A Kalkowska
Jan 22, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Dominika A KalkowskaKimberly M Thompson

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Citations

Apr 28, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M Thompson, Dominika A Kalkowska
Jul 8, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Dominika A KalkowskaKimberly M Thompson
Jul 10, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M Thompson, Dominika A Kalkowska
Nov 12, 2020·Risk Analysis : an Official Publication of the Society for Risk Analysis·Dominika A KalkowskaKimberly M Thompson
Feb 17, 2021·Risk Analysis : an Official Publication of the Society for Risk Analysis·Dominika A Kalkowska, Kimberly M Thompson
Feb 17, 2021·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M Thompson, Dominika A Kalkowska
Feb 17, 2021·Risk Analysis : an Official Publication of the Society for Risk Analysis·Kimberly M Thompson
May 9, 2021·Vaccine·Dominika A KalkowskaKimberly M Thompson
Jul 24, 2021·Open Forum Infectious Diseases·Dominika A KalkowskaKimberly M Thompson

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