Insights from Patterns of SARS-CoV-2 Immunoglobulin G Serology Test Results from a National Clinical Laboratory, United States, March-July 2020.

Population Health Management
Harvey W KaufmanJay G Wohlgemuth

Abstract

Serologic tests for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provide information on past infection and immune response. To better understand the persistence of immune response and the proportion of the population who can develop one, the authors assessed patterns of immunoglobulin G (IgG) positivity over time in individuals tested for SARS-CoV-2 RNA or IgG at a large national reference laboratory. More than 2.4 million SARS-CoV-2 IgG serology (initiated April 21, 2020) and 6.6 million nucleic acid amplification testing (NAAT) (initiated March 9, 2020) results on persons from across the United States as of July 10, 2020 were analyzed. Additional IgG serology results through August 11, 2020 were used for one household analysis. SARS-CoV-2 IgG positivity was observed in 91% (19,434/21,452) of individuals tested after a positive NAAT result and in 10% (7,831/80,968) after a negative NAAT result. Factors associated with seropositivity include age, region of patient residence, and interval between NAAT and IgG serology. The probability of persistent IgG seropositivity declined from 98.6% after 1 week to 74.3% after 2 months, less so in individuals ages ≥55 years than in younger groups. Specimens within 2 days from...Continue Reading

References

Aug 23, 2005·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Nelson LeeDavid S Hui
Feb 1, 2020·The New England Journal of Medicine·Michelle L HolshueUNKNOWN Washington State 2019-nCoV Case Investigation Team
Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
Apr 25, 2020·British Journal of Pharmacology·Cristina ScavoneAnnalisa Capuano
Jun 9, 2020·MedRxiv : the Preprint Server for Health Sciences·Peter D BurbeloJeffrey I Cohen
Jul 9, 2020·Nature Reviews. Immunology·Alessandro Sette, Shane Crotty
Jul 25, 2020·The New England Journal of Medicine·F Javier IbarrondoOtto O Yang

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Citations

Aug 16, 2021·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Mariangela F SilveiraBernardo L Horta

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Methods Mentioned

BETA
nucleic acid amplification
ELISA

Software Mentioned

R
R Foundation for
SAS Studio
SAS

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