Insights from the predicted epitope similarity between Mycobacterium tuberculosis virulent factors and its human homologs

Bioinformation
Venkata Ravi GutlapalliLavanya M Suneetha

Abstract

Mycobacterium tuberculosis is known to be associated with several autoimmune diseases such as systemic lupus erythematous, rheumatoid arthritis and multiple sclerosis. This is attributed to sequence similarity between virulent factors and human proteins. Therefore, it is of interest to identify such regions in the virulent factors to assess potential autoimmune related information. M. tb specific virulent factors were downloaded from the VFDB database and its human homologs were identified using the sequence comparison search tool BLASTP. Both virulent proteins and their corresponding human homologs were further scanned for epitopes (B cell and HLA class I and II allele specific) using prediction programs (BCPRED and NETMHC). Data shows the presence of matching 22 B-cell, 79 HLA class II and 16 HLA class I specific predicted epitopes in these virulent factors having human homologs. A known peptide (HAFYLQYKNVKVDFA) associated with autoimmune atopic dermatitis is shown in the superoxide dismutase homolog structures of the bacterium (PDB ID: 1IDS) and human (PDB ID: 2QKC). This data provides insight into the understanding of infection-associated auto-immunity.

Citations

Jun 28, 2019·Current Topics in Medicinal Chemistry·Meer Asif AliSanjeev Kumar Singh
Sep 7, 2019·Current Topics in Medicinal Chemistry·Anuraj Nayarisseri
May 22, 2019·Current Topics in Medicinal Chemistry·Saphy ShardaSanjeev Kumar Singh
Nov 14, 2019·Current Topics in Medicinal Chemistry·Akanksha LimayeSanjeev Kumar Singh
Oct 9, 2020·BMC Veterinary Research·Manoel Neres Santos JuniorLucas Miranda Marques
Jul 6, 2020·Current Topics in Medicinal Chemistry·Ravina KhandelwalSanjeev Kumar Singh

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Software Mentioned

BCPREDS
Basic Local Alignment Search Tool ( BLAST )
BCPRED
VMD
Ensembl
BLAST
NetMHC
Phobius

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